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首页> 外文期刊>American Journal of Epidemiology >Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis
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Association Between the Ubiquitin Carboxyl-Terminal Esterase L1 Gene (UCHL1) S18Y Variant and Parkinson's Disease: A HuGE Review and Meta-Analysis

机译：泛素羧基末端酯酶L1基因（UCHL1）S18Y变异与帕金森氏病之间的关联：HuGE审查和Meta分析。

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摘要

The ubiquitin carboxyl-terminal esterase L1 gene, UCHL1, located on chromosome 4p14, has been studied as a potential candidate gene for Parkinson's disease risk. The authors conducted a Human Genome Epidemiology review and meta-analysis of published case-control studies of the UCHL1 S18Y variant and Parkinson's disease in Asian and Caucasian samples. The meta-analysis of studies in populations of Asian ancestry showed a statistically significant association between the Y allele and reduced risk of Parkinson's disease under a recessive model (odds ratio (OR) for YY vs. SY + SS = 0.79, 95% confidence interval (CI): 0.67, 0.94; P = 0.006). For a dominant model, the association was not significant in Asian populations (OR for YY + SY vs. SS = 0.88, 95% CI: 0.68, 1.14; P = 0.33). For populations of European ancestry, the meta-analysis showed a significant association between the Y allele and decreased risk of Parkinson's disease under a dominant model (OR = 0.89, 95% CI: 0.81, 0.98; P = 0.02) but not under a recessive model (OR = 0.92, 95% CI: 0.66, 1.30; P = 0.65). Using the Venice criteria, developed by the Human Genome Epidemiology Network Working Group on the assessment of cumulative evidence, the authors concluded that moderate evidence exists for an association between the S18Y variant and Parkinson's disease.
机译：已经研究了位于4p14染色体上的泛素羧基末端酯酶L1基因UCHL1作为帕金森氏病风险的潜在候选基因。作者对亚洲和白种人样本中UCHL1 S18Y变异和帕金森氏病的已发表病例对照研究进行了人类基因组流行病学回顾和荟萃分析。对亚洲血统的研究进行的荟萃分析显示，在隐性模型下，Y等位基因与帕金森氏病风险降低之间存在统计学上的显着相关性（YY与SY + SS的优势比（OR）= 0.79，置信区间为95％） （CI）：0.67，0.94； P ＝ 0.006）。对于主导模型，该关联在亚洲人群中不显着（YY + SY与SS的OR = 0.88，95％CI：0.68，1.14； P = 0.33）。对于欧洲血统的人群，荟萃分析显示，在优势模型下（OR = 0.89，95％CI：0.81、0.98； P = 0.02），Y等位基因与帕金森氏病风险降低之间存在显着相关性，而在隐性模型中则没有模型（OR = 0.92，95％CI：0.66，1.30; P = 0.65）。利用人类基因组流行病学网络工作组针对累积证据评估制定的威尼斯标准，作者得出结论，存在中等证据表明S18Y变异与帕金森氏病之间存在关联。

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  • 来源
    《American Journal of Epidemiology》 |2009年第11期|p.1344-1357|共14页
  • 作者

    Margaret Ragland Carolyn Hutter Cyrus Zabetian and Karen Edwards;

  • 作者单位

    Department of Epidemiology, Univer-sity of Washington School of Public Health, Seattle, Wash-ington (Margaret Ragland, Carolyn Hutter, Karen Edwards),Institute for Public Health Genetics, University of Washing-ton School of Public Health, Seattle, Washington (MargaretRagland, Karen Edwards), Geriatric Research Educationand Clinical Center, Veterans Affairs Puget Sound HealthCare System, Seattle, Washington (Cyrus Zabetian), andDepartment of Neurology, University ofWashington Schoolof Medicine, Seattle, Washington (Cyrus Zabetian).,;

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  • 正文语种 eng
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  • 关键词

    case-control studiesepidemiologygenesgeneticsmeta-analysisParkinson diseasereviewUCHL1;

    机译：病例对照研究流行病学基因遗传遗传元分析帕金森病综述UCHL1;

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