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首页> 外文期刊>American Journal of Neuroradiology >Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography
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Radiation-Induced Xerostomia: Objective Evaluation of Salivary Gland Injury Using MR Sialography

机译：辐射诱发的口干症：MR唾液造影术对唾液腺损伤的客观评估

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BACKGROUND AND PURPOSE: Xerostomia (dry mouth) is one of the serious complications of head and neck irradiation and has a strong influence on a patient's activities of daily living. MR sialography with salivary secretion stimulation provides additional functional information (salivary secretion reserve) and may contribute to the evaluation of the severity of xerostomia and predict the risk of developing a radiation-induced xerostomia. This aim of the study was to analyze MR sialography as an objective tool to evaluate radiation-induced salivary injury. MATERIALS AND METHODS: MR sialography with salivary secretion stimulation was performed in 16 patients with head and neck malignancy before and after irradiation therapy. Multivariate (stepwise multiple regression) analysis was performed to analyze the nonstimulated and stimulated MR sialography findings and the clinical severity of xerostomia. RESULTS: Multivariate analysis of the preirradiation study revealed no significant independent variables that could predict the clinical severity of xerostomia. In the postirradiation study, following regression with 2 independent variables (secretion response of the submandibular gland [rSG] and parotid gland visualization on stimulated MR sialography [sPG]) could explain 70% of the cases: xerostomia severity grade = 0.681 + 0.871 x rSG – 0.471 x sPG. CONCLUSIONS: MR sialography is a useful method for visualization of salivary gland radiation injury and estimation of the severity of radiation-induced xerostomia. Insufficiency of secretion reserve at the irradiated submandibular gland has the strongest influence on xerostomia severity. Our investigation suggests that careful submandibular gland protection may lead to prevention and avoidance of radiation-induced xerostomia.
机译：背景与目的：口干症（口干）是头颈部照射的严重并发症之一，对患者的日常生活活动有很大的影响。 带有唾液分泌刺激的MR唾液造影可以提供 其他功能信息（唾液分泌储备） ，并且可能有助于评估口腔干燥症的严重程度 该研究的目的是分析MR唾液造影作为客观的工具，以评估辐射引起的唾液损伤。 材料与方法：对16例头颈部恶性肿瘤放疗前后进行唾液分泌 刺激的MR唾液造影。进行多变量 （逐步多元回归）分析以分析 未刺激和刺激的MR唾液造影结果和 口腔干燥症的临床严重程度。 / sup>结果：辐照前研究的多变量分析显示 没有显着的自变量可以预测口干症的临床严重程度。在辐照后研究中， 跟随2个独立变量的回归（下颌下腺[rSG]和腮腺的响应）在受激MR唾液造影上的可视化[sPG]）可以解释 70％的情况：口干燥症严重程度= 0.681 + 0.871 x rSG – 0.471 x sPG。 结论：MR唾液造影术是一种有用的方法，可用于可视化 唾液腺辐射损伤和估计辐射诱发的口干症的严重程度 。照射后的下颌下腺分泌不足 对口腔干燥严重程度的影响最大。我们的调查表明 仔细的下颌下腺保护可能会导致预防 和避免辐射引起的口腔干燥。

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    《American Journal of Neuroradiology》 |2009年第1期|53-58|共6页
  • 作者

    A. Wada; N. Uchida; M. Yokokawa; T. Yoshizako; H. Kitagaki;

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    From the Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan;

    From the Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan;

    From the Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan;

    From the Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan;

    From the Department of Radiology, Shimane University Faculty of Medicine, Izumo, Japan;

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