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首页> 外文期刊>American Journal of Neuroradiology >Morbidity and Mortality Associated with Creation of Elastase-Induced Saccular Aneurysms in a Rabbit Model
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Morbidity and Mortality Associated with Creation of Elastase-Induced Saccular Aneurysms in a Rabbit Model

机译：发病率和死亡率与在兔模型中产生的弹性蛋白酶诱导的囊性动脉瘤相关。

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BACKGROUND AND PURPOSE: Elastase-induced aneurysms in rabbits have been proposed as a useful preclinical tool for device development. The object of this study was to report rates of morbidity and mortality associated with the creation and embolization of elastase-induced rabbit aneurysms and to assess the impact of operator experience on these rates. MATERIALS AND METHODS: Elastase-induced model aneurysms were created in New Zealand white rabbits (n = 700). One neuroradiologist/investigator, naive to the aneurysm-creation procedure at the outset of the experiments, performed all surgeries. All morbidity and deaths related to aneurysm creation (n = 700) and embolization procedures (n = 529) were categorized into acute and chronic deaths. Data were analyzed with single-regression analysis and analysis of variance. To assess the impact of increasing operator experience, we broke the number of animals into 50-animal increments. RESULTS: There were 121 (17%) deaths among 700 subjects. Among 700 aneurysm-creation procedures, 59 deaths (8.4%) were noted. Among 529 aneurysm-embolization procedures, 43 deaths (8.1%) were noted. Nineteen additional deaths (2.7% of 700 subjects) were unrelated to the procedures. Simple regression-indicated mortality associated with procedures diminished with increasing operator experience (R2 = 0.38, P = .0180), and that for each 50-rabbit increment mortality was reduced, on average, by 0.6%. CONCLUSIONS: Mortality rates of approximately 8% are associated with both experimental aneurysm creation and with embolization in the rabbit elastase-induced aneurysm model. Increasing operator experience is inversely correlated with mortality, and the age of the rabbit is positively associated with morbidity.
机译：背景与目的：有人提出将弹性蛋白酶诱导的兔动脉瘤 作为器械开发的有用的临床前工具。 本研究的目的是报告发病率和 > 与弹性蛋白酶诱导的 兔子动脉瘤的形成和栓塞相关的死亡率，并评估操作者经验 对这些比率的影响。 材料与方法：弹性蛋白酶诱导的模型动脉瘤 在新西兰白兔（n = 700）中建立。 实验开始时，天真的 神经病学家/研究者完成了动脉瘤手术。所有与动脉瘤形成有关的发病率和死亡 （n = 700）和栓塞程序 （n = 529）均分为急性和慢性死亡。使用单回归分析和 方差分析对数据 进行了分析。为了评估增加操作者体验的影响，我们将动物数量分成了50种动物。 结果：700名受试者中有121人（占17％）死亡。在 700条动脉瘤造血管手术中，有59例死亡（8.4％）。 在529例动脉瘤栓塞过程中，有43例死亡（8.1％） 被注意到。与该程序无关的还有19例死亡（占700名受试者的2.7％）。与操作程序相关的简单回归指示的 死亡率随着 操作员经验的增加而降低（R 2 = 0.38，P = .0180），并且每个 50兔增加死亡率平均降低0.6％。 结论：大约8％的死亡率与两种实验性动脉瘤相关在兔弹性蛋白酶诱导的动脉瘤模型中创建并栓塞 。运算符 的增加与死亡率成反比，兔子的年龄 与发病率成正相关。

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  • 来源
    《American Journal of Neuroradiology》 |2009年第1期|91-94|共4页
  • 作者

    D.A. Lewis; Y.H. Ding; D. Dai; R. Kadirvel; M.A. Danielson; H.J. Cloft; D.F. Kallmes;

  • 作者单位

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

    From the Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minn;

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