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首页> 外文期刊>American Journal of Neuroradiology >Endovascular Coiling of Cerebral Aneurysms Using 'Bioactive' or Coated-Coil Technologies: A Systematic Review of the Literature
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Endovascular Coiling of Cerebral Aneurysms Using 'Bioactive' or Coated-Coil Technologies: A Systematic Review of the Literature

机译：使用“生物活性”或涂层线圈技术对脑动脉瘤进行血管内卷曲：文献的系统评价

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摘要

SUMMARY: Second-generation coils have been available since 2002. We wanted to assess their performance and appraise available evidence. Therefore we performed a systematic review of the literature from 2002 to 2007. There were 27 studies with a total of 2390 patients that met pre-specified inclusion criteria. All studies were classed as having a high risk of bias. There were no randomized trials and for most studies results were not independently assessed and follow-up periods were short (mean 7 months). There were large differences in demographic and aneurysm characteristics, making comparisons between coil cohorts difficult. Procedure-related morbidity and mortality were similar for all coil types. Hemorrhagic events during follow-up were few, in the range of 1%/year for all coil types. The available literature is of poor quality and clinical series provide very little evidence in favor of second-generation coils. Positive randomized trial results are needed to justify routine clinical use. This systematic review illustrates the failure of the industry, the regulatory authorities, and the neurointerventional community combined to provide a reliable and prudent approach to the introduction of new devices.
机译：简介：第二代线圈从2002年开始可用。 我们想评估其性能并评估可用的 证据。因此，我们对2002年至2007年的 文学进行了系统的综述。共有27项研究符合2390例符合预定纳入标准的患者。 / sup>所有研究均被归类为偏倚风险高。没有 没有随机试验，并且大多数研究的结果没有 进行独立评估，并且随访时间很短（平均7个月）。人口统计学 和动脉瘤的特征存在很大差异，因此难以比较线圈 组。与程序相关的发病率和死亡率 对于所有线圈类型均相似。随访期间 的出血事件很少，所有类型的线圈在每年1％的范围内。可用的 文学作品质量很差，临床系列为第二代线圈提供了非常 的小证据。需要肯定的 随机试验结果来证明常规的临床 使用是合理的。这篇系统的评论说明了该行业的失败， 监管机构以及神经介入团体 的结合，从而为引入 提供了可靠而审慎的方法。新设备。

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  • 来源
    《American Journal of Neuroradiology》 |2009年第2期|219-226|共8页
  • 作者

    P.M. White; J. Raymond;

  • 作者单位

    International Consortium of Neuroendovascular Centres [ICONE], Interventional Neuroradiology Research Unit, Department of Radiology, University of Montreal, CHUM Notre-Dame Hospital, Montreal, Canada|Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK;

    International Consortium of Neuroendovascular Centres [ICONE], Interventional Neuroradiology Research Unit, Department of Radiology, University of Montreal, CHUM Notre-Dame Hospital, Montreal, Canada;

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