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首页> 外文期刊>American Journal of Neuroradiology >Malignancy-Associated Vessel Tortuosity: A Computer-Assisted, MR Angiographic Study of Choroid Plexus Carcinoma in Genetically Engineered Mice
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Malignancy-Associated Vessel Tortuosity: A Computer-Assisted, MR Angiographic Study of Choroid Plexus Carcinoma in Genetically Engineered Mice

机译：恶性肿瘤相关的血管曲折：基因工程小鼠脉络丛癌的计算机辅助MR血管造影研究。

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BACKGROUND AND PURPOSE: The ability to assess tumor malignancy and monitor treatment response noninvasively would be of value to both clinicians and animal investigators. This report describes the MR imaging characteristics of a genetically engineered mouse model of choroid plexus carcinoma (CPC) during tumor growth and progression to malignancy. We assess the ability of vessel tortuosity measurements, as calculated from high-resolution MR angiographic (MRA) images, to detect emerging CPC cancers. METHODS: MR images of 9 healthy mice and of 20 CPC mice with precancerous choroid dysplasia or with cancer over a wide range of sizes were analyzed. Two vessel tortuosity measures and a measure of vessel attenuation (vessel count) were calculated from MRA images. Malignancy assessment was based upon a statistical analysis of vessel tortuosity, by using an equation derived from an earlier study of human brain tumor patients. RESULTS: Choroid dysplasia was correctly judged nonmalignant. On the basis of vessel count, neoangiogenesis could not be detected until cancers were full-blown and had reached a volume of approximately 80 mm3. Vessel tortuosity measurements, however, correctly identified emerging malignancy in lesions larger than 0.3 mm3. CONCLUSION: To the best of our knowledge, this report provides the first description of in vivo, MR imaging characteristics of genetically engineered CPC mice during the progression from dysplasia to cancer. Vessel tortuosity measurements offer promise of correctly defining even tiny tumors as malignant.
机译：背景与目的：评估肿瘤恶性和无创监测治疗反应的能力对临床医生和动物研究者均具有价值。该报告描述了在脉管丛状癌（CPC）肿瘤生长和发展为恶性肿瘤的过程中，基因工程小鼠 模型的MR成像特征。我们评估从高分辨率 MR血管造影（MRA）图像计算得出的血管 弯曲度测量值检测新兴CPC癌症的能力。 方法：分析了9名健康小鼠和20名患有 癌前脉络膜异型增生或癌的大范围MR图像。从MRA图像中计算出两个血管弯曲度测量值和一个 血管衰减量（容器计数）。恶性评估是基于对血管曲折性的统计分析，该方程使用的是从较早的人类脑肿瘤患者研究中得出的方程。 结果：正确判断脉络膜异型增生为非恶性。 根据血管计数，直到癌变成熟并达到大约 <的数量，才能检测到新血管生成 。 / sup> 80毫米 3 。但是，血管曲折度测量可以正确识别 大于0.3 mm 3 的病变中的恶性肿瘤。 结论：据我们所知，本报告提供 对转基因CPC小鼠从 发育异常到癌症的体内MR成像特征的首次描述。血管曲折度测量提供了将 正确定义为微小肿瘤为恶性肿瘤的希望。

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  • 来源
    《American Journal of Neuroradiology》 |2006年第3期|00000612-00000619|共8页
  • 作者

    E. Bullitt; P.A. Wolthusen; L. Brubaker; W. Lin; D. Zeng; T. Van Dyke;

  • 作者单位

    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC;

    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC;

    Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC;

    Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC;

    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC;

    Department of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC;

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