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首页> 外文期刊>American Journal of Neuroradiology >Radioactive Coil Embolization of Intracranial Aneurysms: Minimal Inventory to Reach Target Activities in a Virtual Series of 154 patients
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Radioactive Coil Embolization of Intracranial Aneurysms: Minimal Inventory to Reach Target Activities in a Virtual Series of 154 patients

机译：颅内动脉瘤的放射性线圈栓塞：最小清单，以达到目标活动的虚拟系列的154名患者。

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BACKGROUND AND PURPOSE: Recanalization after selective endovascular treatment of intracranial aneurysms with platinum coils has been widely reported in the literature. Beta radiation emitted from 32P ion–implanted coils can prevent recanalization in animal models. A complete inventory of radioactive coils may not be realistic; our hypothesis was that it might not be necessary to reach target activities in most aneurysms. A limited supply of three or four types of coils may decrease the inventory difficulties related to the use of an isotope with a half-life of 2 weeks. METHODS: We reviewed 154 aneurysms selectively treated with standard coils. We calculated the volumetric activity obtained if all coils (simulation 1) were radioactive with linear activities of 0.13 (scenario I) or 0.26 µCi/cm (scenario II). Then, we simulated a treatment with standard coils plus a selection of radioactive coils limited to three (simulation 2) or four types of commonly used coils (simulation 3). Resulting activities were calculated and reported to the lesion volume. For each scenario and simulation, the percentage of lesions, in which the target volumetric activity (0.018 µCi/mm 3) was reached, was reported. RESULTS: Success in reaching target volumetric activities varied from 55–99% according to different simulations. A supply of four types of coils was sufficient to reach target activities in 86–95% of patients commonly treated in our institution. Target activities were difficult to reach in giant aneurysms. CONCLUSION: It is feasible to reach target activities in most lesions by using a limited coil supply.
机译：背景与目的：在文献中广泛报道了选择性铂金线圈进行血管内 颅内动脉瘤治疗后的再通气 。从 32 P离子注入线圈发出的 的Beta辐射可以防止动物模型中的再通气 。完整的放射性线圈清单 可能不切实际。我们的假设是在大多数动脉瘤中 不一定达到目标活动。供应三种或四种类型的线圈的有限 可能会减少与使用半衰期 为2的同位素有关的库存 困难 方法：我们回顾了154例用 标准线圈选择性治疗的动脉瘤。如果所有线圈（模拟1）具有线性活度 为0.13（方案I）或0.26 µCi / cm（方案II），则我们计算得到的体积活度 。然后， 我们用标准线圈模拟了一种处理，并选择了 放射性线圈，将其限制为三种（模拟2）或四种 类型的常用线圈（模拟3）。计算得到的活动 并报告给病变体积。对于每个 场景和模拟，达到目标体积活动（0.018 µCi / mm 3 ）的损伤百分比， > 。 结果：根据不同的模拟，达到目标体积活动的成功率从55％到99％不等。四种类型的线圈的供应量 足以达到我们机构通常治疗的患者的86–95％。 结论：利用有限的线圈供应量可以在大多数 病变中达到目标活动。

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    《American Journal of Neuroradiology》 |2004年第8期|00001377-00001380|共4页
  • 作者

    Charbel Mounayer; Michel Piotin; Jacques Moret; Jean Raymond;

  • 作者单位

    Department of Interventional Neuroradiology Fondation Ophtalmique Adolphe Rothschild, Paris, France;

    Department of Interventional Neuroradiology Fondation Ophtalmique Adolphe Rothschild, Paris, France;

    Department of Interventional Neuroradiology Fondation Ophtalmique Adolphe Rothschild, Paris, France;

    the Department of Radiology, Centre Hospitalier de l’Université de Montréal Notre-Dame Hospital, Montreal, Quebec, Canada;

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