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首页> 外文期刊>American Journal of Neuroradiology >Correlation between Percentage of Brain Parenchymal Volume and Neurocognitive Performance in HIV-Infected Patients
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Correlation between Percentage of Brain Parenchymal Volume and Neurocognitive Performance in HIV-Infected Patients

机译：HIV感染患者脑实质体积百分比与神经认知能力的相关性

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BACKGROUND AND PURPOSE: This study was designed to determine whether neuropsychological function in HIV-infected persons is correlated with loss of brain volume (as measured by percentage of brain parenchymal volume [PBV]). We hypothesized that whole-brain parenchymal volume might correlate with neuropsychologic performance, even before overt clinical dysfunction is apparent. METHODS: A computer-assisted segmentation technique with thin section MR imaging was used for 15 patients with HIV infection (seven symptomatic, eight asymptomatic) and for five HIV-negative control participants to quantify whole brain and CSF volumes. To determine the degree of brain atrophy, the PBV relative to that of intracranial content was calculated. Neuropsychological performance was assessed by using a standard battery of eight tests (NPZ-8 test battery). RESULTS: HIV-infected patients had significantly lower NPZ-8 scores (t[18] = 2.26, P < .05) and lower PBV (t[18] = 1.79, P < .01) than those of healthy control participants. With the Spearman rank order correlation coefficients, data analyzed for all 20 study participants (15 HIV-infected patients and five noninfected control participants) showed a significant (r = -0.50, P < .05) negative correlation between PBV and NPZ-8 test battery score. In addition, there was a significant negative correlation between subtest score of motor impairment and PBV (r = -0.69, P < .01) and between AIDS dementia complex score (r = -0.64) and PBV (P < .01). CONCLUSION: These correlations suggest that quantitation of PBV may offer an objective, easily acquired surrogate predictor of neuropsychological impairment and clinically apparent cognitive/motor dysfunction among HIV-infected persons.
机译：背景与目的：本研究旨在确定 艾滋病毒感染者的神经心理功能是否与脑容量损失相关（以百分比 衡量） >脑实质体积[PBV]）。我们假设，即使在明显的临床功能障碍出现之前，全脑实质体积可能与神经心理表现相关。 方法：计算机辅助分割15例HIV感染 （7例症状，8例无症状）和5例HIV阴性 对照参与者使用了MR成像技术定量全脑和CSF量。 要确定脑萎缩程度，计算相对于颅内内容物的PBV。通过使用八次 测试的标准电池（NPZ-8测试电池）评估神经心理学的表现。结果：感染艾滋病毒的患者的低得多NPZ-8 得分（t [18] = 2.26，P <.05）和较低的PBV（t [18] = 1.79， P <.01）健康对照参与者。使用 Spearman等级顺序相关系数，对所有20名研究参与者（15名HIV感染患者和 五名未感染对照参与者）进行的数据分析 PBV与 NPZ-8测试电池得分之间的显着性 （r = -0.50，P <.05）负相关。此外，运动障碍亚测得分 与PBV之间显着 负相关（r = -0.69，P <.01），艾滋病痴呆综合症 得分（r = -0.64）和PBV（P <.01）。 结论：这些相关性表明 PBV的定量分析可以提供一个客观的，易于获得的HIV感染者的神经心理障碍和临床上明显的认知/运动 功能障碍的替代预测物 。

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  • 来源
    《American Journal of Neuroradiology》 |2002年第4期|543-549|共7页
  • 作者

    Sohil H. Patel; Dennis L. Kolson; Guila Glosser; Isabel Matozzo; Yulin Ge; James S. Babb; Lois J. Mannon; Robert I. Grossman;

  • 作者单位

    Department of Radiology (S.H.P., Y.G., L.J.M., R.I.G.), Hospital of the University of Pennsylvania;

    Department of Neurology (D.L.K., G.G.), Hospital of the University of Pennsylvania;

    Department of Neurology (D.L.K., G.G.), Hospital of the University of Pennsylvania;

    Department of Medicine (I.M.), Hospital of the University of Pennsylvania;

    Department of Radiology (S.H.P., Y.G., L.J.M., R.I.G.), Hospital of the University of Pennsylvania;

    Department of Biostatistics (J.S.B.), Fox Chase Cancer Center, Philadelphia, PA;

    Department of Radiology (S.H.P., Y.G., L.J.M., R.I.G.), Hospital of the University of Pennsylvania;

    Department of Radiology (S.H.P., Y.G., L.J.M., R.I.G.), Hospital of the University of Pennsylvania;

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