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首页> 外文期刊>PLoS One >Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients
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Neurocognitive dysfunction and brain FDG-PET/CT findings in HIV-infected hemophilia patients and HIV-infected non-hemophilia patients

机译：艾滋病毒感染血友病患者的神经认知功能障碍和脑FDG-PET / CT调查结果和艾滋病毒感染的非血友病患者

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摘要

This single-institution cross-sectional study aimed to grasp the prevalence and features of neurocognitive dysfunction in HIV-infected hemophilia patients in Japan. We conducted neuropsychological tests and medical examinations in 56 HIV-infected hemophilia patients who received outpatient treatment at the AIDS Clinical Center, National Center for Global Health and Medicine. A total of 388 HIV-infected non-hemophilia patients who received outpatient treatment at the same institution were included as a control group. To investigate sites responsible for neurocognitive dysfunction in HIV-infected hemophilia patients using brain FDG-PET/CT scans, the accumulation of FDG in each brain region was compared. Approximately 50% of HIV-infected hemophilia patients had neurocognitive dysfunction. The prevalence of asymptomatic neurocognitive impairment was high (34%). Neurocognitive dysfunction was associated with educational level in HIV-infected hemophilia patients. In the symptomatic group, hemophilic arthropathy and history of cerebrovascular disorders were associated with neurocognitive dysfunction. Left temporal lobe function was reduced in the symptomatic group.
机译：这种单机构的横断面研究旨在掌握日本艾滋病毒感染血友病患者神经认知功能障碍的患病率和特征。我们在56名艾滋病毒感染的血友病患者中进行了神经心理学检测和体检，在艾滋病临床中心，国家全球健康和医学中心接受门诊治疗。共有388名艾滋病毒感染的非血友病患者在同一机构接受门诊治疗作为对照组。为了研究使用脑FDG-PET / CT扫描的艾滋病毒感染的血友病患者负责艾滋病毒感染功能障碍的遗址，比较了每个脑区中的FDG积累。大约50％的艾滋病毒感染的血友病患者具有神经认知功能障碍。无症状神经认知障碍的患病率高（34％）。神经认知功能障碍与艾滋病毒感染血友病患者的教育水平有关。在症状组中，血友病性关节病和脑血管障碍的历史与神经认知功能障碍有关。左颞叶功能在症状组中降低。

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