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首页> 外文期刊>American Journal of Neuroradiology >Functional MR Imaging Analysis of Pain-related Brain Activation after Acute Mechanical Stimulation
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Functional MR Imaging Analysis of Pain-related Brain Activation after Acute Mechanical Stimulation

机译:急性机械刺激后疼痛相关的大脑激活的功能性MR成像分析。

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BACKGROUND AND PURPOSE: Most studies concerning imaging of pain processing have used thermal, chemical, or electrical nociceptive stimulation. The aim of the present study was to determine the cortical representation of mechanical pain. For this, using functional MR (fMR) imaging at 1.5 T, we compared activation patterns during painful and nonpainful tonic mechanical stimulation in healthy volunteers. METHODS: Eleven right-handed subjects ranging in age from 21 to 46 years underwent gradient-echo echo-planar fMR imaging while quantified tonic pressure was applied to the first metacarpophalangeal joint. Imaging parameters were 3000/60 (TR/TE) with a 5-mm section thickness in a 7.30-minute sequence with 2 x 90 seconds of painful stimulation interleaved with 3 x 90 seconds of nonpainful stimulation. Functional images were processed using dedicated IDL software. RESULTS: Mechanical tonic nociceptive pressure was associated with activation of the primary somatosensory cortex contralateral to the hand stimulated and variable, often bilateral activation of the secondary somatosensory, temporal, anterior and posterior cingulate, insular, and prefrontal cortexes. Thalamic activation was inconsistent and always contralateral to stimulation. CONCLUSION: The interindividual variability found in this fMR imaging study calls for repetitive single-subject analysis or more extensive studies of large groups of patients. Either may be based on fMR imaging analysis of brain activation after tonic mechanically induced pain, which leads to deep pain sensation similar to patients' painful sensations most commonly encountered in clinical practice.
机译:背景与目的:大多数关于疼痛 加工成像的研究都使用了热,化学或电伤害性 刺激。本研究的目的是确定机械疼痛的 皮质表示。为此,我们使用功能性MR(fMR)在1.5 T下成像,我们比较了健康志愿者在疼痛和非疼痛性强直性机械刺激 期间的激活 模式。 方法:对年龄在21 到46岁之间的11位右撇子受试者进行了梯度-回波-平面fMR成像 ,同时定量了强直压力应用于第一个掌指 关节。成像参数为3000/60(TR / TE),厚度为5毫米,厚度 ,顺序为7.30分钟,疼痛刺激2 x 90秒,交错刺激3 x,间隔2 x 90秒90秒的无痛刺激。 使用专用IDL软件处理功能图像。 结果:机械性强直性伤害感受压力与主体感激活有关对侧皮层对侧刺激 并刺激,通常是次级体感,颞侧,前侧和后侧 扣带回,皮层和前额皮层的双侧激活 。丘脑激活 与刺激不一致,总是对立的。 结论:在此fMR 成像研究中发现的个体差异要求进行重复的单项分析或 对大型患者进行了更广泛的研究。 可能基于基于fMR影像学分析的强直性 机械性疼痛后的大脑激活,这会导致类似于患者的疼痛感觉的深痛感在临床实践中最常见的

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  • 来源
    《American Journal of Neuroradiology》 |2000年第8期|1402-1406|共5页
  • 作者单位

    From INSERM U.378 (M.A.) and Service de Neuroradiologie/Neurologie CHU de Bordeaux (C.C., P.H., J.M.C.).;

    From INSERM U.378 (M.A.) and Service de Neuroradiologie/Neurologie CHU de Bordeaux (C.C., P.H., J.M.C.).;

    From INSERM U.378 (M.A.) and Service de Neuroradiologie/Neurologie CHU de Bordeaux (C.C., P.H., J.M.C.).;

    From INSERM U.378 (M.A.) and Service de Neuroradiologie/Neurologie CHU de Bordeaux (C.C., P.H., J.M.C.).;

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