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首页> 外文期刊>Analytical Chemistry >On-Chip Drop-to-Drop Liquid Microextraction Coupled with Real-Time Concentration Monitoring Technique
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On-Chip Drop-to-Drop Liquid Microextraction Coupled with Real-Time Concentration Monitoring Technique

机译：片上滴滴液体微萃取结合实时浓度监测技术

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摘要

ABSTRACT: This paper demonstrates a novel drop-to-drop liquid-liquid micro-nextraction (DTD-LLME) device, which is based on an electrowetting on dielectricn(EWOD) digital microfluidic chip. Droplets of two immiscible liquids, one of whichnis an ionic liquid, are formed in nanoliter volumes, driven along electrodes, mergednand mixed for extraction, and finally separated upon the completion of the extractionnprocess. All the steps are carried out on a microfluidic chip using combined electro-nwetting and dielectrophoretic forces, which act on the droplet upon the application ofnelectric potential. Specially, the phase separation of two immiscible nanoliter-scalenliquid drops was achieved for the firsttimeonanEWODdigitalmicrofluidic chip. Tonstudy the on-chip extraction kinetics, an image-based concentration measurementntechnique with suitable color parameters was studied and compared with the typicalnUV absorption based technique. Finally, the effect of applied ac voltage frequencyontheextractionkineticswas studied. The observationsnon DTD-LLME, particularly phase separation, are discussed. The image-based method was found to be applicable for precise concentra-ntion measurements with the right choice of the color parameter. Results from experiments on finding the frequency dependence onnextraction kinetics demonstrate that the application of higher frequencies can be a factor in accelerating the extraction on the proposednmicroextraction device.
机译：摘要：本文演示了一种新型的滴滴液-液微萃取（DTD-LLME）设备，该设备基于电介质（EWOD）数字微芯片上的电润湿。两种不混溶的液体（其中一种为离子液体）的液滴以纳升体积形成，沿电极驱动，并入并混合以进行萃取，并在萃取过程完成后最终分离。所有步骤均在微流体芯片上使用组合的电润湿力和介电泳力进行，这些力在施加电势时作用于液滴。特别是，第一次使用EWOD数字微流体芯片实现了两个不混溶的纳升级液滴的相分离。通过研究片上提取动力学，研究了具有合适颜色参数的基于图像的浓度测量技术，并将其与典型的基于UV吸收的技术进行了比较。最后，研究了施加交流电压频率对提取动力学的影响。讨论了非DTD-LLME的观察，特别是相分离。发现基于图像的方法适用于正确选择颜色参数的精确浓度测量。从发现频率依赖性非萃取动力学的实验结果表明，较高频率的应用可能是加速拟议的微萃取装置上萃取的一个因素。

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