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首页> 外文期刊>Analytical chemistry >On-Chip Drop-to-Drop Liquid Microextraction Coupled with Real-Time Concentration Monitoring Technique
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On-Chip Drop-to-Drop Liquid Microextraction Coupled with Real-Time Concentration Monitoring Technique

机译：片上滴滴液体微萃取结合实时浓度监测技术

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摘要

This paper demonstrates a novel drop-to-drop liquid-liquid microextraction (DTD-LLME) device, which is based on an electrowetting on dielectric (EWOD) digital microfluidic chip. Droplets of two immiscible liquids, one of which is an ionic liquid, are formed in nanoliter volumes, driven along electrodes, merged and mixed for extraction, and finally separated upon the completion of the extraction process. All the steps are carried out on a microfluidic chip using combined electrowetting and dielectrophoretic forces, which act on the droplet upon the application of electric potential. Specially, the phase separation of two immiscible nanoliter-scale liquid drops was achieved for the first time on an EWOD digital microfluidic chip. To study the on-chip extraction kinetics, an image-based concentration measurement technique with suitable color parameters was studied and compared with the typical UV absorption based technique. Finally, the effect of applied ac voltage frequency on the extraction kinetics was studied. The observations on DTD-LLME, particularly phase separation, are discussed. The image-based method was found to be applicable for precise concentration measurements with the right choice of the color parameter. Results from experiments on finding the frequency dependence on extraction kinetics demonstrate that the application of higher frequencies can be a factor in accelerating the extraction on the proposed microextraction device.
机译：本文演示了一种新型的滴滴液-液微萃取（DTD-LLME）装置，该装置基于电介质上电润湿（EWOD）数字微流控芯片。两种不混溶的液体（其中之一是离子液体）的液滴以纳升体积形成，沿着电极驱动，合并并混合以进行萃取，并在萃取过程完成后最终分离。所有步骤都是在微流体芯片上使用组合的电润湿力和介电泳力进行的，在施加电势时，它们会作用在液滴上。特别是，在EWOD数字微流控芯片上首次实现了两个不混溶的纳升级液滴的相分离。为了研究片上提取动力学，研究了具有合适颜色参数的基于图像的浓度测量技术，并将其与典型的基于紫外线吸收的技术进行了比较。最后，研究了施加交流电压频率对萃取动力学的影响。讨论了有关DTD-LLME的观察，特别是相分离。发现基于图像的方法适用于正确选择颜色参数的精确浓度测量。从发现频率对萃取动力学的依赖关系的实验结果表明，较高频率的应用可能是加快拟议微萃取装置萃取速度的一个因素。

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