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The physiology of bacterial cell division

机译:细菌细胞分裂的生理

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Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers. Divisome assembly occurs in two steps and involves multiple interactions between more than 20 essential and accessory cell division proteins. Well before constriction and while the cell is still elongating, the tubulin-like FtsZ and early cell division proteins form a ring-like structure at mid-cell. Cell division starts once certain peptidoglycan enzymes and their activators have moved to the FtsZ-ring. Gram-negative bacteria like Escherichia colt simultaneously synthesize and cleave the septum peptidoglycan during division leading to a constriction. The outer membrane constricts together with the peptidoglycan layer with the help of the transenvelope spanning Tol-Pal system.
机译:divisome是一种动态的多蛋白装配体,位于中层细胞中,可合成细菌承受压力的肽聚糖,并收缩所有细胞包膜层,从而促进细菌细胞分裂。多样化的组装过程分为两个步骤,涉及20多种必需和辅助细胞分裂蛋白之间的多重相互作用。收缩前和细胞仍在伸长时,微管蛋白样的FtsZ和早期细胞分裂蛋白在中层细胞形成环状结构。一旦某些肽聚糖酶及其激活剂移至FtsZ环,细胞分裂便开始。革兰氏阴性菌(如大肠埃希氏菌)在分裂过程中同时合成并裂解中隔肽聚糖,导致收缩。外膜在跨Tol-Pal系统的跨包膜的帮助下与肽聚糖层一起收缩。

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