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Introduction to Antimicrobial Therapeutics Reviews The bacterial cell wall as an antimicrobial target

机译:抗菌治疗学导论评论细菌细胞壁作为抗菌靶标

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Bacterial cell walls are unique structures that serve as ideal targets for antimicrobial drugs. Agents that interfere with bacterial cell wall biosynthesis or cell integrity have been used therapeutically with high efficacy and good safety since the 1940s.1'2 Because there is no comparable structure in mammalians, bacterial cell wall inhibitors can exhibit high target specificity with side effect profiles that are not target related, unlike some other classes of antibiotics. In addition, cell wall-active agents are frequently bactericidal in their action, providing the opportunity for complete bacterial clearance in serious infections.
机译:细菌细胞壁是独特的结构,可作为抗菌药物的理想靶标。自1940年代以来,干扰细菌细胞壁生物合成或细胞完整性的药物已在治疗上以高疗效和良好的安全性使用。1'2由于哺乳动物中没有可比的结构,细菌细胞壁抑制剂可表现出高靶点特异性并具有副作用与其他目标类别的抗生素不同,它们与目标无关。另外,细胞壁活性剂通常在其作用中具有杀菌作用,从而为严重感染中的细菌完全清除提供了机会。

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