Phosphoinositide 3-kinase and INPP4B in human breast cancer

Micka C.Bertucci; Christina A. Mitchell

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Phosphoinositide 3-kinase and INPP4B in human breast cancer

机译：磷酸肌醇3-激酶和INPP4B在人类乳腺癌中的作用

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The PI3K/Akt signaling pathway is frequently increased in many human cancers, including breast cancer. Recent studies have identified INPP4B, which inhibits PI3K signaling, as an emerging tumor suppressor in breast cancer. This short review discusses these issues and the possibility that INPP4B is an important regulator in many cancers.

机译：在许多人类癌症中，包括乳腺癌，PI3K / Akt信号传导途径经常增加。最近的研究已经确定，抑制PI3K信号传导的INPP4B是乳腺癌中新兴的肿瘤抑制因子。这篇简短的评论讨论了这些问题以及INPP4B是许多癌症中重要调节剂的可能性。

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来源
《Annals of the New York Academy of Sciences》 |2013年第2013期|1-5|共5页
作者
Micka C.Bertucci; Christina A. Mitchell;
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作者单位

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia;

Department of Biochemistry and Molecular Biology, Monash University,Clayton, Victoria 3800, Australia;

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原文格式 PDF
正文语种 eng
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关键词
PI3K; breast cancer; PTEN; 4-phosphatase; INPP4B;

机译：PI3K;乳腺癌;PTEN;4-磷酸酶;INPP4B;

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1. Roles of human epidermal growth factor receptor 2, c-jun NH2-terminal kinase, phosphoinositide 3-kinase, and p70 S6 kinase pathways in regulation of cyclin G2 expression in human breast cancer cells. [J] . Le XF, Arachchige-Don AS, Mao W, Molecular cancer therapeutics . 2007,第11期

机译：人表皮生长因子受体2，c-jun NH2末端激酶，磷酸肌醇3激酶和p70 S6激酶途径在调控人乳腺癌细胞中cyclin G2表达中的作用。
2. Exploring Biomarkers of Phosphoinositide 3-Kinase Pathway Activation in the Treatment of Hormone Receptor Positive, Human Epidermal Growth Receptor 2 Negative Advanced Breast Cancer [J] . Virginia G. Kaklamani, Andrea L. Richardson, Carlos L. Arteaga The oncologist . 2019,第3期

机译：探索磷酸阳性的生物标志物3-激酶途径激活治疗激素受体阳性，人体表皮生长受体2阴性晚期乳腺癌
3. Disulfiram treatment facilitates phosphoinositide 3-kinase inhibition in human breast cancer cells in vitro and in vivo. [J] . Zhang H, Chen D, Ringler J, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010,第10期

机译：双硫仑治疗在体外和体内促进人乳腺癌细胞中磷酸肌醇3-激酶的抑制。
4. Phosphoinositide 3-kinase and INPP4B in human breast cancer [C] . Micka C. Bertucci, Christina A. Mitchell Inositol Phospholipid Signaling in Physiology and Disease (Conference) . 2013

机译：磷酸阳性3-激酶和人类乳腺癌中的INPP4B
5. SIRT1 represses estrogen-signaling, ligand-independent estrogen receptor alpha-mediated transcription, and cell proliferation in breast cancer cells via inhibition of the phosphoinositide 3-kinases pathway [D] . Moore, Robert L. 2011

机译：SIRT1通过抑制磷酸肌醇3激酶途径抑制雌激素信号传导，配体独立的雌激素受体α介导的转录和乳腺癌细胞的增殖
6. Disulfiram Treatment Facilitates Phosphoinositide 3-Kinase Inhibition in Human Breast Cancer Cells In vitro and In vivo [O] . Haijun Zhang, Di Chen, Jonathan Ringler, -1

机译：双硫仑治疗功能有助于磷酸肌醇3-激酶的抑制作用在人乳腺癌细胞在体外和体内
7. Phosphoinositide 3-Kinase is involved in the tumor-specific activation of human breast cancer cell Na+/H+ exchange, motility, and invasion induced by serum deprivation [O] . RESHKIN SJ, BELLIZZI A, ALBARANI V, 2000

机译：Phosphoinositide 3-Kinase参与人类乳腺癌细胞Na + / H +交换，运动和血清剥夺诱导的侵袭的肿瘤特异性激活
8. AKT2 Oncogene and Phosphoinositide 3-Kinase in Human Breast Cancer [R] . Cheng, J. Q. 2004

机译：人类乳腺癌中的aKT2致癌基因和磷酸肌醇3-激酶

Phosphoinositide 3-kinase and INPP4B in human breast cancer

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