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首页> 外文期刊>Annals of the New York Academy of Sciences >Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States
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Type 2 diabetes in East Asians: similarities and differences with populations in Europe and the United States

机译：东亚人的2型糖尿病：与欧洲和美国人群的异同

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摘要

There is an epidemic of diabetes in Asia. Type 2 diabetes develops in East Asian patients at a lower mean body mass index (BMI) compared with those of European descent. At any given BMI, East Asians have a greater amount of body fat and a tendency to visceral adiposity. In Asian patients, diabetes develops at a younger age and is characterized by early β cell dysfunction in the setting of insulin resistance, with many requiring early insulin treatment. The increasing proportion of young-onset and childhood type 2 diabetes is posing a particular threat, with these patients being at increased risk of developing diabetic complications. East Asian patients with type 2 diabetes have a higher risk of developing renal complications than Europeans and, with regard to cardiovascular complications, a predisposition for developing strokes. In addition to cardiovascular-renal disease, cancer is emerging as the other main cause of mortality. While more research is needed to explain these interethnic differences, urgent and concerted actions are needed to raise awareness, facilitate early diagnosis, and encourage preventive strategies to combat these growing disease burdens.
机译：在亚洲，糖尿病流行。与欧洲血统的患者相比，东亚患者的2型糖尿病平均体重指数（BMI）较低。在任何给定的BMI中，东亚人的体内脂肪含量都较高，并且容易出现内脏脂肪。在亚洲患者中，糖尿病在年轻时发展，其特征是在胰岛素抵抗的背景下早期β细胞功能异常，许多患者需要早期胰岛素治疗。青年发病率和儿童期2型糖尿病的比例不断增加构成特殊威胁，这些患者患糖尿病并发症的风险增加。与欧洲人相比，东亚2型糖尿病患者发生肾脏并发症的风险更高，并且在心血管并发症方面，更容易发生中风。除了心血管肾脏疾病，癌症正在成为导致死亡的另一个主要原因。尽管需要更多的研究来解释这些种族间的差异，但仍需要采取紧急和协调的行动来提高认识，促进早期诊断并鼓励采取预防策略来应对这些日益严重的疾病负担。

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