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首页> 外文期刊>Annals of the New York Academy of Sciences >Hemoglobin concentration and anemia diagnosis in venous and capillary blood: biological basis and policy implications
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Hemoglobin concentration and anemia diagnosis in venous and capillary blood: biological basis and policy implications

机译：静脉和毛细血管血红蛋白浓度和贫血的诊断：生物学基础和政策意义

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Anemia is an important public health challenge and accurate prevalence estimates are needed for program planning and tracking progress. While venous blood assessed by automated hematology analyzers is considered gold standard, most population-based surveys use point-of-care diagnostics and capillary blood to estimate population prevalence of anemia. Several factors influence hemoglobin (Hb) concentration, including human and analytic error, analysis method, and type of instrument, but it is unclear whether biological variability exists between venous and capillary blood. The objective of this paper was to systematically review sources of Hb variability and the potential biological basis for venous and capillary differences. We use data from a recent survey in the state of Uttar Pradesh, India, to illustrate the implications on anemia prevalence estimates. Significant differences in Hb concentration between capillary and venous blood samples are common. Most but not all find capillary Hb concentration to be higher than venous. Instrument/method variability and human error play an important role, but cannot fully explain these differences. A normative guide to data collection, analysis, and anemia diagnosis is needed to ensure consistent and appropriate interpretation. Further research is needed to fully understand the biological implications of venous and capillary Hb variability.
机译：贫血是一项重要的公共卫生挑战，需要准确的流行估计数才能规划计划和跟踪进展。虽然通过自动血液分析仪评估的静脉血被认为是金标准，但大多数基于人群的调查都使用即时诊断和毛细管血来估计贫血人群的患病率。影响血红蛋白（Hb）浓度的几个因素包括人为误差和分析误差，分析方法和仪器类型，但尚不清楚静脉血和毛细血管血之间是否存在生物学差异。本文的目的是系统地审查血红蛋白变异性的来源以及静脉和毛细血管差异的潜在生物学基础。我们使用印度北方邦最近的一项调查数据来说明对贫血患病率估计值的影响。毛细血管和静脉血样本之间的血红蛋白浓度存在明显差异。大多数但并非全部发现毛细管血红蛋白浓度高于静脉血。仪器/方法的可变性和人为错误起着重要作用，但不能完全解释这些差异。需要有关数据收集，分析和贫血诊断的规范指南，以确保一致且适当的解释。需要进一步研究以充分了解静脉和毛细管血红蛋白变异性的生物学意义。

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