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首页> 外文期刊>Annals of the New York Academy of Sciences >Extraesophageal syndrome of gastroesophageal reflux: relationships with lung disease and transplantation outcome
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Extraesophageal syndrome of gastroesophageal reflux: relationships with lung disease and transplantation outcome

机译：胃食管反流的异味综合征：与肺病和移植结果的关系

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Gastroesophageal reflux disease (GERD) is prevalent and may be associated with both esophageal and extraesophageal syndromes, which include various pulmonary conditions. GERD may lead to pulmonary complications through the "reflux" (aspiration) or "reflex" (refluxate-triggered, vagally mediated airway spasm) mechanisms. While GERD may cause or worsen pulmonary disorders, changes in respiratory mechanics due to lung disease may also increase reflux. Typical esophageal symptoms are frequently absent and objective assessment with reflux monitoring is often needed for diagnosis. Impedance monitoring should be considered in addition to traditional pH study due to the involvement of both acidic and weakly acidiconacidic reflux. Antireflux therapy may improve outcomes of some pulmonary complications of GERD, although careful selection of a candidate is paramount to successful outcomes. Further research is needed to identify the optimal testing strategy and patient phenotypes that would benefit from antireflux therapy to improve pulmonary outcomes.
机译：胃食管反流疾病（GERD）是普遍的，可能与食管和异味综合征有关，包括各种肺部条件。 GERD可能通过“回流”（抽吸）或“反射”（回流触发，漫长介导的气道痉挛）机制来导致肺并发症。虽然GERD可能导致或恶化肺病，但由于肺病导致的呼吸系统的变化也可能增加回流。典型的食管症状通常不存在，并且通常需要使用反流监测进行客观评估。由于酸性和弱酸性/非侵害回流的累及，除了传统的pH研究之外，应考虑阻抗监测。抗反法疗法可能会改善壮观的一些肺部并发症的结果，尽管仔细选择候选人至关重要的成功结果。需要进一步研究以确定将从抗反射治疗中受益以改善肺果的最佳测试策略和患者表型。

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