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首页> 外文期刊>Applied Mathematical Modelling >Peristaltic transport of a particulate suspension in the small intestine
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Peristaltic transport of a particulate suspension in the small intestine

机译：小肠颗粒悬浮液的蠕动运输

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Food transport through different sections of the gastrointestinal tract for the purposes of digestion and waste removal is an essential physiological function for life. Mechanical and chemical breakdown of food takes place throughout the gastrointestinal tract. Periodic muscular contraction and relaxation of the intestinal walls agitate, mix and propel the multiphase digesta along the intestines. Experimental measurement of flow inside the intestines is difficult therefore understanding of food transport through the majority of the gut is limited. Computational models for predicting the transient behaviour of intestinal content subject to peristaltic activity offer the possibility for assessing the digestive performance of different foods. We present a numerical model for peristalsis in the duodenum using a suspension of rigid particulates in a viscous Newtonian fluid to represent simple digesta. This consists of a thin viscoelastic membrane representing the gut wall coupled to the particle-based methods Smoothed Particle Hydrodynamics (SPH) and Discrete Element Method (DEM) which are used to predict the motion of liquid and solids content respectively. Peristaltic waves travel along the gut wall resulting in active muscular contractions and relaxations of the gut. The bulk motion of the content shows both phases move together due to the laminar nature of the flow with only very short-term inter-phase differences found in the relaxation region and in the wake of the contraction. Propulsive events were found to cause significant non-homogeneity of the solids distribution along the length of the duodenum. The inclusion of solids mildly modifies the overall propulsive flow behaviour and the retrograde jet in the wake of the contraction. In the absence of solids and connective tissue constraints, a transverse wobbling instability in the fluid filled viscoelastic tube is observed.
机译：为了消化和清除废物，食物通过胃肠道的不同部分运输是生命的基本生理功能。食物的机械和化学分解发生在整个胃肠道中。周期性的肌肉收缩和肠壁松弛会搅动，混合并沿肠推进多相消化。肠内流量的实验测量是困难的，因此对通过大部分肠道的食物运输的理解受到限制。用于预测肠内容物在蠕动作用下的瞬时行为的计算模型为评估不同食物的消化性能提供了可能性。我们提出了一种十二烷基肠蠕动的数值模型，该模型使用刚性牛顿流体中的刚性颗粒悬浮液来代表简单的消化。它由代表肠壁的粘弹性薄膜组成，该薄膜与基于颗粒的方法（平滑颗粒流体动力学（SPH）和离散元素方法（DEM））耦合，分别用于预测液体和固体的运动。蠕动波沿着肠壁传播，导致主动性肌肉收缩和肠松弛。内容物的整体运动表明，由于流的层流性质，两个相一起移动，在松弛区域和收缩后仅发现非常短的相间差。发现推进事件导致沿十二指肠长度的固体分布明显不均匀。收缩后，固体的加入温和地改变了整体的推进流动行为和逆行射流。在没有固体和结缔组织约束的情况下，在充满流体的粘弹性管中观察到横向摆动不稳定性。

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