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首页> 外文期刊>Applied Mathematical Modelling >Prediction of thrombus formation using vortical structures presentation in Stanford type B aortic dissection: A preliminary study using CFD approach
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Prediction of thrombus formation using vortical structures presentation in Stanford type B aortic dissection: A preliminary study using CFD approach

机译：使用斯坦福B型主动脉夹层中的旋涡结构表现预测血栓形成：使用CFD方法的初步研究

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摘要

False lumen patency has been recognized as the key determinant of aneurismal dilatation and rupture, whereas complete thrombosis has been proven clinically to improve disease outcomes. However, to date, there is no definitive method that could predict false lumen thrombosis in Stanford type B aortic dissection patient. The present study aims to use the evolution of vortical structures throughout a cardiac cycle and its interaction with the wall shear stress (WSS) to illustrate the potential mechanism behind the formation of thrombus and predict its highly possible location in an aortic dissection patient. A three-dimensional (3D) patient-specific Stanford type B aortic dissection domain was generated from computed tomography (CT) angiographic images. The effects of false lumen size on vortical structures and the subsequent risk of thrombus formation were investigated. The Carreau-Yasuda model, representing non-Newtonian fluid property was used to study the difference between Newtonian and non-Newtonian fluid settings on vortical structures. Based on our analysis, we predicted that the formation and thickening of thrombus is very much likely to occur at the posterior false lumen wall, distal to the entry tear region, in the patient. Higher λ_2 intensity, associated with a higher maximum WSS and a lower minimum WSS, was achieved with an increase in the false lumen size, and we believed that this increases the risk of thrombus formation and thus aneurismal dilatation. On the other hand, percentage of flow entering the false lumen increased with an increase in the false lumen size, leading to a downward shift of the areas of thrombus formation along the false lumen wall.
机译：错误的管腔通畅度已被认为是动脉瘤扩张和破裂的关键决定因素，而在临床上已证明完全血栓形成可改善疾病预后。然而，迄今为止，尚无确定的方法可以预测斯坦福B型主动脉夹层患者的假管腔血栓形成。本研究旨在利用整个心动周期中旋涡结构的演变及其与壁切应力（WSS）的相互作用来阐明血栓形成背后的潜在机制，并预测其在主动脉夹层患者中的高度可能位置。从计算机断层扫描（CT）血管造影图像生成三维（3D）患者特定的斯坦福B型主动脉夹层域。研究了假管腔大小对旋涡结构的影响以及随后血栓形成的风险。代表非牛顿流体性质的Carreau-Yasuda模型用于研究涡旋结构上牛顿流体和非牛顿流体设置之间的差异。根据我们的分析，我们预测在患者中，在进入撕裂区远端的后假管腔壁极有可能发生血栓的形成和增厚。较高的λ_2强度与较高的最大WSS和较低的最小WSS相关联，是通过增加假管腔大小来实现的，我们相信这会增加血栓形成的风险，从而增加动脉瘤扩张的风险。另一方面，随着假管腔尺寸的增加，进入假管腔的流量百分比增加，导致血栓形成区域沿着假管腔壁向下移动。

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  • 来源
    《Applied Mathematical Modelling》 |2016年第4期|3115-3127|共13页
  • 作者

    Wan Naimah Wan Ab Naim; Poo Balan Ganesan; Zhonghua Sun; Yih Miin Liew; Yi Qian; Chang-Joon Lee; Shirley Jansen; Shahrul Amry Hashim; Einly Lim;

  • 作者单位

    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Department of Medical Radiation Sciences, Curtin University, Perth 6845, Australia;

    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    The Australian School of Advanced Medicine, 2 Technology Place, Macquarie University, New South Wales 2109, Australia;

    The Australian School of Advanced Medicine, 2 Technology Place, Macquarie University, New South Wales 2109, Australia;

    Department of Vascular Surgery, Sir Charles Gairdner Hospital, Nedlands 6009, Australia,School of Population Health, Curtin University, Perth 6845, Australia;

    Department of Surgery, Faculty of Medicine Building, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Stanford type B aortic dissection; Vortical structures; Thrombus; Computational fluid dynamics; False lumen; Hemodynamics;

    机译：斯坦福大学B型主动脉夹层;涡流结构;血栓;计算流体动力学;假腔;血液动力学;

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