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Numerical simulation of continuous separation of microparticles in two-stage acousto-microfluidic systems

机译：两阶段声微流体系统中微粒连续分离的数值模拟

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摘要

Numerical modelling of acousto-microfluidic particle manipulation systems cannot only be used to explain the complex phenomena observed in experiments, but can also be applied to optimise their performances. In this work, we present numerical simulations of continuous-flow-based two-stage acoustic microparticle separations with a reduced-fluid model, which is consisted of three main parts: (1) an acoustic focusing zone; (2) a transition zone; and (3) an acoustic separation zone. The acoustophoresis of microparticles of various sizes in the fluid channel was modelled based on Newton's second law, where the acoustic radiation forces and the flow-induced drag forces, the main driving terms for particle motion, were solved from the Gorkov equation and the Navier-Stokes equations, respectively. It was found that an acoustic focusing process configured with appropriate force amplitudes can focus all particles to the same flow vector before entering the separation zone and thus can improve the separation efficiency, and that a sheath flow injected from the transition zone can push the sample flow onto the side boundaries, which can broaden the effective separation range for more robust separations. Based on the mechanism analyses, we here numerically demonstrated acoustofluidic separation of 5 different particle fractions simultaneously in a continuous microfluidic channel ending with 9 equally spaced outlets. We also predicted here that, with carefully designed acoustic and flow fields, it is capable to acoustically separate two different particle fractions with a diameter difference of 4% (difference in acoustic mobility of only -1.08).
机译：声学微流体粒子操纵系统的数值模拟不能用于解释在实验中观察到的复杂现象，但也可以应用于优化其性能。在这项工作中，我们呈现了与减液模型的连续流动的两级声学微粒分离的数值模拟，其中包括三个主要部分：（1）声学聚焦区; （2）过渡区; （3）声学分离区。基于牛顿的第二律建模流体通道中各种尺寸的微粒的声蛋白，其中声辐射力和流量引起的阻力，颗粒运动的主要驾驶术语从Gorkov方程和Navier求解 - 分别为方程式。结果发现，在进入分离区之前，配置有适当的力幅度的声学聚焦过程可以将所有颗粒聚焦到相同的流量矢量，从而可以提高分离效率，并且从过渡区注入的鞘流可以推动样品流动在侧边界上，可以扩大有效的分离范围以获得更强大的分离。基于机制分析，我们在线上以具有9个等间隔的出口的连续微流体通道同时在数值上显示出5种不同的颗粒级分的声学分离。我们还预测，通过精心设计的声学和流场，它能够在声学上分离两个不同的粒子级分，直径差为4％（仅-1.08的声学迁移率差）。

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  • 来源
    《Applied Mathematical Modelling》 |2020年第7期|342-356|共15页
  • 作者

    Junjun Lei; Feng Cheng; Kemin Li; Zhongning Guo;

  • 作者单位

    State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology Cuangzhou 510006 China Guangzhou Key Laboratory of Non-traditional Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou 510006 China;

    State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology Cuangzhou 510006 China Guangzhou Key Laboratory of Non-traditional Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou 510006 China;

    State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology Cuangzhou 510006 China Guangzhou Key Laboratory of Non-traditional Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou 510006 China;

    State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of Technology Cuangzhou 510006 China Guangzhou Key Laboratory of Non-traditional Manufacturing Technology and Equipment Guangdong University of Technology Guangzhou 510006 China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Acoustic particle separation; Acoustic radiation force; Continuous flow; Acoustophoresis; Standing waves; Microfluidics;

    机译：声颗粒分离;声学辐射力;连续流动;声渗;站立的波浪;微流体;

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