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Cardiovascular Correlates of Motor Vehicle Accident Related Posttraumatic Stress Disorder and its Successful Treatment

机译:与机动车辆事故相关的创伤后应激障碍的心血管相关因素及其成功治疗

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摘要

Persons with posttraumatic stress disorder (PTSD) have been shown to display elevated baseline cardiovascular activity and a heightened physiological reactivity to trauma-related stimuli. Study 1 examined differences in baseline heart rate (HR) and HR reactivity in 68 survivors of motor vehicle accidents (MVAs) and healthy controls without MVA., MVA survivors with PTSD (n = 26), subsyndromal PTSD (n = 22), traumatized controls without PTSD (non-PTSD with MVA, n =20) and healthy controls without MVA (HC, n=27) underwent measurement of HR during baseline and exposure to a neutral, positive, negative, and trauma-related picture. PTSD patients showed elevated baseline HR and increased HR reactivity only during exposure to the trauma-related picture. Study 2 investigated whether the elevated physiological responses observed in Study 1 normalized after cognitive behavioral therapy (CBT). We conducted a randomized, controlled treatment trial comparing CBT (n=17) to a Wait-list condition (WLC, n = 18). Results showed a greater decrease in HR reactivity for CBT than for WLC. The change in HR reactivity was associated with clinical improvement.
机译:创伤后应激障碍(PTSD)患者表现出较高的基线心血管活动和对创伤相关刺激的生理反应。研究1研究了68名机动车事故(MVA)幸存者和无MVA的健康对照者,PTSD的MVA幸存者(n = 26),综合征下PTSD(n = 22),受创伤的基线心率(HR)和HR反应性的差异无PTSD的对照(非PTSD的MVA,n = 20)和健康的无MSD的对照(HC,n = 27)在基线期间以及暴露于中性,阳性,阴性和创伤相关图片的过程中均进行HR测量。 PTSD患者仅在暴露于创伤相关图片期间显示基线HR升高和HR反应性增加。研究2调查了认知行为疗法(CBT)后研究1中观察到的升高的生理反应是否正常。我们进行了一项随机对照研究,比较了CBT(n = 17)和等待治疗的病情(WLC,n = 18)。结果显示,与WLC相比,CBT的HR反应性降低更大。 HR反应性的变化与临床改善有关。

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