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首页> 外文期刊>Applied Surface Science >Surface modification of polypropylene mesh devices with cyclodextrin via cold plasma for hernia repair: Characterization and antibacterial properties
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Surface modification of polypropylene mesh devices with cyclodextrin via cold plasma for hernia repair: Characterization and antibacterial properties

机译：通过冷等离子体用环糊精对聚丙烯网状装置进行表面改性以修复疝气：表征和抗菌性能

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摘要

Light weight polypropylene (PP) mesh is the most widely used implant among all other synthetic meshes for hernia repair. However, infection is the complication associated to all synthetic meshes after hernia repair. Thus, to manage mesh related infection; antibacterial drug is generally loaded to surgical implants to supply drug locally in mesh implanted site. Nevertheless, PP mesh restricts the loading of antibacterial drug at operated area due to its low wettability. The aim of this study was to introduce a novel antimicrobial PP mesh modified with beta-cyclodextrine (CD) and loaded with antimicrobial agent for infection prevention. A cold oxygen plasma treatment was able to activate the surfaces of polypropylene fibers, and then CD was incorporated onto the surfaces of PP fibers. Afterward, triclosan, as a model antibacterial agent, was loaded into CD cavity to provide desired antibacterial functions. The modified polypropylene mesh samples CD-Tric-1, CD-Tric-3 exhibited excellent inhibition zone and continuous antibacterial efficacy against E. coli and S. aureus up to 6 and 7 days respectively. Results of AFM, SEM, FTIR and antibacterial tests evidenced that oxygen plasma process is necessary to increase chemical connection between CD molecules and PP fibers. The samples were also characterized by using EDX, XRD, TGA, DSC and water contact angle. (C) 2017 Elsevier B.V. All rights reserved.
机译：轻质聚丙烯（PP）网格是所有其他用于疝气修复的合成网格中使用最广泛的植入物。但是，感染是疝修补后所有人造网相关的并发症。因此，要管理网状相关感染；通常将抗菌药物加载到外科植入物上，以在网状植入部位中局部供应药物。然而，PP网由于其低润湿性而限制了在手术区域的抗菌药物的装载。这项研究的目的是介绍一种新型的经PP-β-环糊精（CD）修饰并装有抗菌剂以预防感染的PP网片。冷氧等离子体处理能够活化聚丙烯纤维的表面，然后将CD掺入PP纤维的表面。然后，将三氯生作为典型的抗菌剂装入CD腔中，以提供所需的抗菌功能。改性聚丙烯网状样品CD-Tric-1，CD-Tric-3分别对大肠杆菌和金黄色葡萄球菌分别具有长达6天和7天的优异抑菌圈和连续抗菌效果。 AFM，SEM，FTIR和抗菌测试的结果表明，氧等离子体过程对于增加CD分子与PP纤维之间的化学连接是必不可少的。还通过使用EDX，XRD，TGA，DSC和水接触角来表征样品。 （C）2017 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2018年第may1期|749-759|共11页
  • 作者

    Sanbhal Noor; Mao Ying; Sun Gang; Xu Rui Fang; Zhang Qian; Wang Lu;

  • 作者单位

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

    Donghua Univ, Minist Educ, Coll Text, Key Lab Text Sci & Technol, Shanghai 201620, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Antibacterial; Cyclodextrin incorporation; Hernia meshes; Polypropylene;

    机译：抗菌;环糊精掺入;Hernia网眼;聚丙烯;

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