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首页> 外文期刊>Applied Surface Science >Construction of a multifunctional coating consisting of phospholipids and endothelial progenitor cell-specific peptides on titanium substrates
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Construction of a multifunctional coating consisting of phospholipids and endothelial progenitor cell-specific peptides on titanium substrates

机译：在钛基质上构建由磷脂和内皮祖细胞特异性肽组成的多功能涂层

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摘要

A phospholipid/peptide polymer (PMMDP) with phosphorylcholine groups, endothelial progenitor cell (EPC)-specific peptides and catechol groups was anchored onto a titanium (Ti) surface to fabricate a biomimetic multifunctional surface. The PMMDP coating was characterized by X-ray photoelectron spectroscopy (XPS), water contact angle measurements and atomic force microscopy (AFM), respectively. The amount of PMMDP coating on the Ti surface was quantified by using the quartz crystal microbalance with dissipation (QCM-D). Interactions between blood components and the coated and bare Ti substrates were evaluated by platelet adhesion and activation assays and fibrinogen denaturation test using platelet rich plasma (PRP). The results revealed that the PMMDP-modified surface inhibited fibrinogen denaturation and reduced platelet adhesion and activation. EPC cell culture on the PMMDP-modified surface showed increased adhesion and proliferation of EPCs when compared to the cells cultured on untreated Ti surface. The inhibition of fibrinogen denaturation and platelet adhesion and support of EPCs attachment and proliferation indicated that this coating might be beneficial for future applications in blood-contacting implants, such as vascular stents. (C) 2015 Elsevier B.V. All rights reserved.
机译：具有磷酰胆碱基团，内皮祖细胞（EPC）特异性肽和邻苯二酚基团的磷脂/肽聚合物（PMMDP）被固定在钛（Ti）表面上，以制造仿生多功能表面。通过X射线光电子能谱（XPS），水接触角测量和原子力显微镜（AFM）分别对PMMDP涂层进行了表征。通过使用带耗散的石英晶体微天平（QCM-D）定量测定了Ti表面的PMMDP涂层量。使用富含血小板的血浆（PRP），通过血小板粘附和激活测定以及血纤蛋白原变性测试，评估了血液成分与涂覆的Ti基底和裸露的Ti基底之间的相互作用。结果表明，PMMDP修饰的表面抑制了纤维蛋白原变性，并降低了血小板粘附和活化。与在未经处理的Ti表面上培养的细胞相比，在PMMDP修饰的表面上的EPC细胞培养物显示出EPC的粘附和增殖增加。对纤维蛋白原变性和血小板粘附的抑制以及对EPC附着和增殖的支持表明，这种涂层可能有利于将来在与血液接触的植入物（如血管支架）中的应用。 （C）2015 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2015年第30期|169-177|共9页
  • 作者

    Chen Huiqing; Li Xiaojing; Zhao Yuancong; Li Jingan; Chen Jiang; Yang Ping; Maitz Manfred F.; Huang Nan;

  • 作者单位

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China|Max Bergmann Ctr Biomat Dresden, Leibniz Polymer Res Dresden, D-01069 Dresden, Germany;

    Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Educ Minist, Chengdu 610031, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Titanium; Phospholipid; Specific peptide; Endothelial progenitor cells; Biomimetic multifunctional coating;

    机译：钛;磷脂;特异肽;内皮祖细胞;仿生多功能涂层;

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