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首页> 外文期刊>Applied Surface Science >Bovine serum albumin bioconjugated graphene oxide: Red blood cell adhesion and hemolysis studied by QCM-D
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Bovine serum albumin bioconjugated graphene oxide: Red blood cell adhesion and hemolysis studied by QCM-D

机译：牛血清白蛋白生物共轭氧化石墨烯：QCM-D研究红细胞黏附和溶血

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摘要

Graphene oxide (GO) had great potential in various applications especial biomedical materials. In this study, we improved the hemocompatibility especial hemolysis properties of GO nanosheets by grafting bovine serum albumin (BSA). The hemocompatibility of GO-g-BSA was improved. The hemolysis ratio of GO-g-BSA was lower than 0.2% and no visible hemoglobin release was observed. In a flowed condition, the interaction between GO and RBC was monitored real time by quartz crystal microbalance with dissipation (QCM-D) and the hemolysis rates of eluted RBC solution was determined. The balance between the adsorption and degradation of RBC on the surface of GO was a linear process. The GO-g-BSA surface decreased the adhesion of RBC in a flowed condition, maintained the morphology of RBC and reduced the hemolysis rate in the most effective manner. The inert of BSA resisted GO interacting with the lipid bilayers of RBC and the negative charge on the surface of BSA repelled the approach of negative charged RBC. The excellent hemocompatibility of the BSA modified GO might confer its great potentials for various biomedical applications. 2015 (C) Elsevier B.V. All rights reserved.
机译：氧化石墨烯（GO）在各种应用（特别是生物医学材料）中具有巨大的潜力。在这项研究中，我们通过嫁接牛血清白蛋白（BSA）改善了GO纳米片的血液相容性特别是溶血特性。 GO-g-BSA的血液相容性得到改善。 GO-g-BSA的溶血率低于0.2％，未观察到可见的血红蛋白释放。在流动的情况下，通过具有耗散的石英微天平（QCM-D）实时监测GO和RBC之间的相互作用，并确定洗脱的RBC溶液的溶血速率。 GO表面上RBC的吸附和降解之间的平衡是线性过程。 GO-g-BSA表面在流动状态下降低了RBC的粘附力，保持RBC的形态并降低了溶血速率。 BSA的惰性分子抵抗GO与RBC的脂质双层相互作用，BSA表面的负电荷排斥带负电荷的RBC。 BSA修饰的GO极好的血液相容性可能赋予其在各种生物医学应用中的巨大潜力。 2015（C）Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2015年第30期|844-851|共8页
  • 作者

    Cai Bing; Hu Kebang; Li Chunming; Jin Jing; Hu Yuexin;

  • 作者单位

    Liaoning Shihua Univ, Sch Chem & Mat Sci, Fushun 113001, Peoples R China|Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China;

    Jilin Univ, Dept Urol, Hosp 1, 4 Changchun 130021, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China;

    Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China;

    Liaoning Shihua Univ, Sch Chem & Mat Sci, Fushun 113001, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Graphene oxide; Bovine serum albumin; QCM-D; Hemolysis;

    机译：氧化石墨烯;牛血清白蛋白;QCM-D;溶血;

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