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首页> 外文期刊>Applied Surface Science >Effect of processing methods on drug release profiles of anti-restenotic self-assembled monolayers
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Effect of processing methods on drug release profiles of anti-restenotic self-assembled monolayers

机译：加工方法对抗再狭窄自组装单层药物释放曲线的影响

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The use of anti-restenotic self-assembled monolayers (ARSAMs) has been previously demonstrated for delivering drugs from stents without polymeric carriers. ARSAMs have been prepared by coating an anti-restenotic drug (paclitaxel - PAT) on -COOH terminated phosphonic acid self-assembled monolayers (SAMs) coated Co-Cr alloy specimens. This study investigates the effect of different processing methods on the percentage of drug release from ARSAMs. The different methods that were used in this study to process ARSAMs include room temperature (RT) treatment, heat treatment (HT), cold treatment (CT) and quenching. The changes in polymorphism, chemical structure, morphology, and distribution of PAT on SAMs coated specimens were investigated using differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and atomic force microscopy (AFM), respectively. DSC showed dihydrate, dehydrated dihydrate, semi-crystalline, and mixed (amorphous and dihydrate) forms of PAT for RT, HT, CT, and quenched specimens, respectively. FTIR showed that the chemical structure of PAT was unaltered in all the specimens processed by various methods employed in this study. SEM showed a mixture of spherical, ovoid, and bean-shaped morphologies of PAT on RT, HT, and CT while particle-like and needle-shaped morphologies of PAT were observed on quenched specimens. AFM showed PAT was uniformly distributed on RT, HT and CT specimens while particle-like PAT was well distributed and needle-shaped PAT was sparsely distributed on quenched specimens. CT specimens showed greater density of PAT crystals when compared to other methods. Thus, this study demonstrated that processing methods have significant influence on the polymorphism, morphology, and distribution of PAT on SAMs coated Co-Cr alloy specimens. The in vitro drug elution studies for up to 56 days showed sustained release for all the different groups of specimens. CT showed lesser percentage of drug release when compared to that of other methods on the first day. The treatment at high temperatures (HT-100℃ or HT-140℃) improved the stability of PAT on alloy surfaces and showed lesser percentage of drug release when compared to that of RT or HT-70 C at different time points. Large data scatter was observed for the release profiles of quenched specimens. No other major differences in the percentage of drug release were observed for the specimens prepared by different processing methods. These factors should be taken into consideration when drug delivery platforms are developed for stents or other medical devices.
机译：先前已经证明了使用抗再狭窄自组装单层膜（ARSAMs）从没有聚合物载体的支架中递送药物。通过在-COOH端接的膦酸自组装单层（SAMs）涂覆的Co-Cr合金样品上涂覆抗再狭窄药物（紫杉醇-PAT），可以制备ARSAM。这项研究调查了不同处理方法对ARSAMs药物释放百分比的影响。本研究中用于处理ARSAM的不同方法包括室温（RT）处理，热处理（HT），冷处理（CT）和淬火。使用差示扫描量热法（DSC），傅立叶变换红外光谱（FTIR），扫描电子显微镜（SEM）和原子力显微镜（AFM）研究了SAMs涂层样品上PAT的多态性，化学结构，形态和分布的变化。 ， 分别。 DSC显示分别用于RT，HT，CT和淬火样品的PAT的二水合物，脱水的二水合物，半结晶和混合（无定形和二水合物）形式。 FTIR显示，通过本研究采用的各种方法处理的所有标本中，PAT的化学结构均未改变。扫描电镜显示，在RT，HT和CT上，PAT呈球形，卵形和豆形形态的混合物，而在淬火后的样品中观察到PAT呈颗粒状和针形形态。原子力显微镜显示PAT在RT，HT和CT试样上均匀分布，而颗粒状PAT分布均匀，针状PAT稀疏分布在淬火试样上。与其他方法相比，CT标本显示出更高的PAT晶体密度。因此，这项研究表明加工方法对SAMs涂层Co-Cr合金样品上PAT的多态性，形态和分布有重要影响。长达56天的体外药物洗脱研究表明，所有不同组的标本均能持续释放。与第一天的其他方法相比，CT显示的药物释放百分比较低。与在不同时间点的RT或HT-70 C相比，高温（HT-100℃或HT-140℃）的处理提高了PAT在合金表面的稳定性，并显示出较小的药物释放百分比。对于骤冷样品的释放曲线，观察到大量数据散布。对于通过不同加工方法制备的样品，未观察到药物释放百分比的其他主要差异。在为支架或其他医疗设备开发药物输送平台时，应考虑这些因素。

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