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Hybrid surface from self-assembled layer and its effect on protein adsorption

机译：自组装层的杂化表面及其对蛋白质吸附的影响

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摘要

We synthesized hybrid self-assembled monolayer (SAM) with short chain hydrophobic and hydrophilic groups on the same molecule. The physical characteristics such as surface roughness and surface energy of the synthesized hybrid SAM were compared with mono SAMs of amine, octyl and mixed amine-octyl SAM. We also compared the response of the surfaces towards adsorption of bovine serum albumin (BSA) using quartz crystal microbalance (QCM). We determined adsorbed amount (T) of BSA on the various surfaces from its various bulk concentrations. It follows the Langmuir adsorption isotherm in the concentration range of our study. The strength of adsorbed protein was characterized from the dissipation factor (AD). The highest AD value of adsorbed BSA was observed for the adsorption on hybrid surface. The arrangement of BSA on hybrid surface such that it leaded to soft layer, corresponded to the highest AD value. These findings suggest that the hybrid surface is a potential surface modifying agent of biomaterials.
机译：我们合成了在同一分子上具有短链疏水和亲水基团的杂化自组装单分子层（SAM）。将合成的杂化SAM的物理特性，例如表面粗糙度和表面能与胺，辛基和混合的胺-辛基SAM的单SAM进行比较。我们还比较了使用石英晶体微量天平（QCM）对牛血清白蛋白（BSA）吸附表面的响应。我们从各种表面上的各种堆积浓度确定了BSA在各种表面上的吸附量（T）。它遵循我们研究的浓度范围内的Langmuir吸附等温线。吸附蛋白的强度由耗散因子（AD）表征。对于杂化表面的吸附，观察到吸附的BSA的最高AD值。 BSA在混合表面上的排列（导致其到达软层）相当于最高的AD值。这些发现表明，杂化表面是生物材料的潜在表面改性剂。

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