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首页> 外文期刊>Applied Surface Science >Effects of O_2 and N_2/H_2 plasma treatments on the neuronal cell growth on single-walled carbon nanotube paper scaffolds
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Effects of O_2 and N_2/H_2 plasma treatments on the neuronal cell growth on single-walled carbon nanotube paper scaffolds

机译：O_2和N_2 / H_2等离子体处理对单壁碳纳米管纸质支架神经元细胞生长的影响

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摘要

The O_2 and N_2/H_2 plasma treatments of single-walled carbon nanotube (SWCNT) papers as scaffolds for enhanced neuronal cell growth were conducted to functionalize their surfaces with different functional groups and to roughen their surfaces. To evaluate the effects of the surface roughness and functional-ization modifications of the SWCNT papers, we investigated the neuronal morphology, mitochondrial membrane potential, and acetylcholine/acetylcholinesterase levels of human neuroblastoma during SH-SY5Y cell growth on the treated SWCNT papers. Our results demonstrated that the plasma-chemical functionalization caused changes in the surface charge states with functional groups with negative and positive charges and then the increased surface roughness enhanced neuronal cell adhesion, mitochondrial membrane potential, and the level of neurotransmitter in vitro. The cell adhesion and mitochondrial membrane potential on the negatively charged SWCNT papers were improved more than on the positively charged SWCNT papers. Also, measurements of the neurotransmitter level showed an enhanced acetylcholine level on the negatively charged SWCNT papers compared to the positively charged SWCNT papers.
机译：进行了单壁碳纳米管（SWCNT）纸的O_2和N_2 / H_2等离子体处理，以增强神经元细胞的生长，使其表面具有不同的官能团，并使表面变粗糙。为了评估SWCNT纸的表面粗糙度和功能化修饰的影响，我们在处理过的SWCNT纸上研究了人类神经母细胞瘤在SH-SY5Y细胞生长过程中的神经元形态，线粒体膜电位和乙酰胆碱/乙酰胆碱酯酶水平。我们的结果表明，等离子体化学功能化会导致带有负电荷和正电荷的官能团的表面电荷状态发生变化，然后增加的表面粗糙度会增强神经元细胞的粘附力，线粒体膜电位和体外神经递质的水平。带负电的SWCNT纸的细胞粘附力和线粒体膜电位比带正电的SWCNT纸提高了更多。同样，对神经递质水平的测量表明，与带正电的SWCNT纸相比，带负电的SWCNT纸的乙酰胆碱水平更高。

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  • 来源
    《Applied Surface Science》 |2011年第20期|p.8535-8541|共7页
  • 作者

    Ok Ja Yoon; Hyun Jung Lee; Yeong Mi Jang; Hyun Woo Kim; Won Bok Lee; Sung Su Kim; Nae-Eung Lee;

  • 作者单位

    School of Advanced Materials Science and Engineering, Center for Advanced Plasma Surface Technology and Center for Human Interface Nanotechnology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Republic of Korea;

    Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea;

    Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea;

    School of Advanced Materials Science and Engineering, Center for Advanced Plasma Surface Technology and Center for Human Interface Nanotechnology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Republic of Korea;

    Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea;

    Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea;

    School of Advanced Materials Science and Engineering, Center for Advanced Plasma Surface Technology and Center for Human Interface Nanotechnology, Sungkyunkwan University, Suwon, Kyunggi-do 440-746, Republic of Korea;

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  • 正文语种 eng
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  • 关键词

    single-walled carbon nanotube; O_2 and N_2/H_2 plasma treatments; mitochondrial membrane potential; neurotransmitter; scaffolds; neuronal activity;

    机译：单壁碳纳米管;O_2和N_2 / H_2等离子体处理;线粒体膜电位神经递质脚手架神经元活动;

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