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The Application Of New Nanocomposites: Enhancement Effect Of Polylactide Nanofibersano-tio_2 Blends On Biorecognition Of Anticancer Drug Daunorubicin

机译:新型纳米复合材料的应用:聚乳酸纳米纤维/ nano-tio_2共混物对抗癌药物柔红霉素生物识别的增强作用

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In this contribution, the blending of nano-titanium dioxide (TiO_2) and polylactide (PLA) nanohbers has been adopted as a new nanomaterial to facilitate the biorecognition of an anticancer drug daunorubicin. Our observations demonstrate that upon application of the nano-TiO_2-PLA polymer nanocomposites, the drug molecules could be readily self-assembled on the surface of the new nanocomposites so that considerably enhanced detection sensitivity for the DNA binding behavior could be observed for the relative biorecognition. These results may also imply some potential valuable application of the blending of nano-TiO_2 and PLA nanofibersas a kind of drug carriers in view of the respective good biocompatibility and large surface area of the new nanocomposites.
机译:在此贡献中,纳米二氧化钛(TiO_2)和聚丙交酯(PLA)纳米混纺的混合物已被用作一种新的纳米材料,以促进抗癌药物柔红霉素的生物识别。我们的观察结果表明,在应用纳米TiO_2-PLA聚合物纳米复合材料后,药物分子可以很容易地自组装在新的纳米复合材料的表面上,从而可以观察到相对结合的DNA结合行为的检测灵敏度大大提高。 。考虑到新纳米复合材料各自的良好生物相容性和较大的表面积,这些结果也可能暗示将纳米TiO_2和PLA纳米纤维的共混物作为一种药物载体具有潜在的有价值的应用。

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