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Controllable fabrication and characterization of biocompatible core-shell particles and hollow capsules as drug carrier

机译：生物相容性核壳颗粒和中空胶囊作为药物载体的可控制备和表征

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SiO2@CdSe core-shell particles were fabricated by controllable deposition CdSe nanoparticles on silica colloidal spheres. Step-wise coating process was tracked by the TEM and XRD measurements. In addition, SiO2@CdSe/polypyrrole(PPy) multi-composite particles were synthesized based on the as-prepared SiO2@CdSe particles by cationic polymerization. The direct electrochemistry of myoglobin (Mb) could be performed by immobilizing Mb on the surface of SiO2@CdSe particles. Immobilized with Mb, SiO2@CdSe/PPy-Mb also displayed good bioelectrochemical activity. It confirmed the good biocompatible property of the materials with protein. CdSe hollow capsules were further obtained as the removal of the cores of SiO2@CdSe spheres. Hollow and porous character of CdSe sub-meter size capsules made them becoming hopeful candidates as drug carriers. Doxorubicin, a typical an antineoplastic drug, was introduced into the capsules. A good sustained drug release behavior of the loading capsules was discovered via performing a release test in the PBS buffer (pH 7.4) solution at 310 k. Furthermore, SiO2@CdSe/PPy could be converted to various smart hollow capsules via selectively removal of their relevant components. (c) 2005 Elsevier B.V. All rights reserved.
机译：SiO2 @ CdSe核-壳颗粒是通过可控制的CdSe纳米颗粒在二氧化硅胶体球上的沉积而制备的。通过TEM和XRD测量追踪逐步涂覆过程。此外，基于制备的SiO2 @ CdSe颗粒，通过阳离子聚合反应合成了SiO2 @ CdSe /聚吡咯（PPy）多复合颗粒。肌红蛋白（Mb）的直接电化学可以通过将Mb固定在SiO2 @ CdSe颗粒的表面上来进行。固定化了Mb的SiO2 @ CdSe / PPy-Mb也表现出良好的生物电化学活性。它证实了材料与蛋白质的良好生物相容性。通过去除SiO2 @ CdSe球核，进一步获得了CdSe空心胶囊。 CdSe亚米级胶囊的空心和多孔特性使其成为有望成为药物载体的候选药物。阿霉素，一种典型的抗肿瘤药，被引入胶囊。通过在310 k的PBS缓冲液（pH 7.4）溶液中进行释放测试，发现了负载胶囊的良好持续药物释放行为。此外，SiO2 @ CdSe / PPy可以通过有选择地去除其相关成分而转化为各种智能空心胶囊。 （c）2005 Elsevier B.V.保留所有权利。

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