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首页> 外文期刊>RSC Advances >Development of biocompatible hydroxyapatitepoly-(ethylene glycol) core-shell nanoparticles as an improved drug carrier: structural and electrical characterizations
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Development of biocompatible hydroxyapatitepoly-(ethylene glycol) core-shell nanoparticles as an improved drug carrier: structural and electrical characterizations

机译：生物相容性羟基磷酸盐 - （乙二醇）核壳纳米粒子的研制为改进药物载体：结构和电气特性

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摘要

Hydroxyapatite-5 wt% poly(ethylene glycol) (HA-PEG) core-shell composite nanoparticles (NPs) were synthesized using a coprecipitation technique. For the first time, the NPs are characterized for potential drug delivery applications using structural, electrical and in vitro kinetic studies. Phase quantification and the crystal structures of the NPs were analyzed using X-ray diffraction and Fourier transform infrared spectroscopy and the morphology was determined using scanning electron and transmission electron microscopies. Dielectric spectroscopy was used to analyze the polarization behaviour of the HA and HA-PEG core-shell NPs as potential drug carriers by applying an oscillating (100 Hz to 2.5 MHz) electric field. The increased intra-particle interfacial interactions in the HA-PEG NPs confirmed the significant enhancement in interfacial or space charge polarization owing to the reduction in mobility and accumulation of charge-carriers at the interfaces. Thus, HA-PEG showed better aceclofenac drug releasing properties than pristine HA NPs. An in vitro cell study confirmed that the HA and HA-PEG core-shell nanocarriers showed excellent biocompatibility on human dermis fibroblast (HDF) cells. The interaction within the HA-PEG core-shell was stronger than with pristine HA and the biodegradable PEG from the shell-layer neutralized the composite-surroundings path. Hence, it would reduce the direct interaction of aceclofenac drug with the surrounding biomolecules of the delivery paths and enhance the ability for carrying the drug precisely to the target organs.
机译：使用共沉淀技术合成羟基磷灰石-5wt％聚（乙二醇）（HA-PEG）核 - 壳复合纳米颗粒（NPS）。首次，NPS的特征在于使用结构，电气和体外动力学研究的潜在药物递送应用。使用X射线衍射和傅里叶变换红外光谱分析NPS的相位化和NPS的晶体结构，并且使用扫描电子和透射电子显微镜测定形态。通过施加振荡（100Hz至2.5MHz）电场，使用介电光谱分析HA和Ha-PEG核心 - 壳NPS作为潜在药物载体的偏振行为。由于界面在界面处的电荷载体的迁移率降低，HA-PEG NPS中的增加的颗粒界面相互作用确认了界面或空间电荷极化的显着增强。因此，HA-PEG显示出比原始HA NPS更好的醋氯芬酸药物释放性质。体外细胞研究证实，HA和Ha-PEG核心 - 壳纳米载体在人类真皮成纤维细胞（HDF）细胞上具有优异的生物相容性。 Ha-PEG核心 - 壳内的相互作用比原始HA和可生物降解的PEG从壳层中和复合围绕物流路径中和。因此，它将减少醋氯芬酸药物与递送路径的周围生物分子的直接相互作用，并提高依赖于靶器官携带药物的能力。

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  • 来源
    《RSC Advances》 |2016年第105期|共16页
  • 作者

    Manna Ayan; Pramanik Sumit; Tripathy Ashis; Moradi Ali; Radzi Zamri; Pingguan-Murphy Belinda; Hasnan Nazirah; Abu Osman Noor Azuan;

  • 作者单位

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

    Univ Malaya Fac Dent Dept Paediat Dent &

    Orthodont Kuala Lumpur 50603 Malaysia;

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

    Univ Malaya Fac Med Dept Rehabil Med Kuala Lumpur 50603 Malaysia;

    Univ Malaya Dept Biomed Engn Ctr Appl Biomech Fac Engn Kuala Lumpur 50603 Malaysia;

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