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Indocyanine green modified silica shells for colon tumor marking

机译：吲哚菁绿改性硅胶壳，用于结肠肿瘤标记

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摘要

Marking colon tumors for surgery is normally done with the use of India ink. However, non-fluorescent dyes such as India ink cannot be imaged below the tissue surface and there is evidence for physiological complications such as abscess, intestinal perforation and inconsistency of dye injection. A novel infrared marker was developed using FDA approved indocyanine green (ICG) dye and ultrathin hollow silica nanoshells (ICG/HSS). Using a positively charged amine linker, ICG was non-covalently adsorbed onto the nanoparticle surface. For ultra-thin wall 100 nm diameter silica shells, a bimodal ICG layer of < 3 nm is was formed. Conversely, for thicker walls on 2 mu m diameter silica shells, the ICG layer was only bound to the outer surface and was 6 nm thick. In vitro testing of fluorescent emission showed the particles with the thinner coating were considerably more efficient, which is consistent with self-quenching reducing emission shown in the thicker ICG coatings. Ex-vivo testing showed that ICG bound to the 100 nm hollow silica shells was visible even under 1.5 cm of tissue. In vivo experiments showed that there was no diffusion of the ICGanoparticle marker in tissue and it remained imageable for as long as 12 days.
机译：通常使用印度墨水对结肠肿瘤进行手术标记。但是，非荧光染料（如印度墨水）无法在组织表面以下成像，并且有生理并发症（如脓肿，肠穿孔和染料注射不一致）的证据。使用FDA批准的吲哚菁绿（ICG）染料和超薄空心二氧化硅纳米壳（ICG / HSS）开发了一种新型的红外标记。使用带正电荷的胺接头，将ICG非共价吸附到纳米颗粒表面。对于直径100 nm的超薄壁二氧化硅壳，形成了<3 nm的双峰ICG层。相反，对于直径为2μm的二氧化硅壳上的较厚壁，ICG层仅与外表面结合，厚度为6 nm。荧光发射的体外测试表明，具有较薄涂层的颗粒的效率要高得多，这与较厚的ICG涂层中显示的自猝灭降低了发射相一致。离体测试表明，即使在1.5 cm的组织下，结合到100 nm空心二氧化硅壳上的ICG仍然可见。体内实验表明，ICG /纳米颗粒标记物在组织中没有扩散，可成像长达12天。

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  • 来源
    《Applied Surface Science》 |2020年第1期|143885.1-143885.10|共10页
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    Univ Calif San Diego Dept Nanoengn 9500 Gilman Dr La Jolla CA 92093 USA;

    Univ Calif San Diego Dept Surg 9500 Gilman Dr La Jolla CA 92093 USA;

    Univ Calif San Diego Dept Radiol 9500 Gilman Dr La Jolla CA 92093 USA;

    Univ Calif San Diego Dept Chem & Biochem 9500 Gilman Dr La Jolla CA 92093 USA;

    Univ Texas Dallas Dept Mat Sci & Engn 800 West Campbell Rd Richardson TX 75080 USA;

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  • 正文语种 eng
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  • 关键词

    Indocyanine green; India ink; Tumor marking; Silica shell; Heterogeneous dye; Self-quenching;

    机译：吲哚菁绿;印墨;肿瘤标记;硅胶壳;异质染料;自淬火;

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