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首页> 外文期刊>Archiv der Pharmazie >Anti-inflammatory, Analgesic, Anticonvulsant and Antiparkinsonian Activities of Some Pyridine Derivatives Using 2,6-Disubstituted Isonicotinic Acid Hydrazides
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Anti-inflammatory, Analgesic, Anticonvulsant and Antiparkinsonian Activities of Some Pyridine Derivatives Using 2,6-Disubstituted Isonicotinic Acid Hydrazides

机译：使用2,6-二取代的异烟酸酰肼的某些吡啶衍生物的抗炎，止痛，抗惊厥和抗帕金森病活性

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摘要

A series of novel thiazolo derivatives 2–15 was synthesized by initial condensation of 2,6-dihydroxyisonicotinohydrazide 1 and 2-chloro-6-hydrazinylisonicotinohydrazide 11 with different organic reagents. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory, analgesic, anticonvulsant, and antiparkinsonian activities comparable to diclofenac potassium, Voltarene®, Carbamazepine®, and Benzotropene® as reference drugs. Initially the acute toxicity of the compounds was assayed via the determination of their LD50. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, 13C-NMR, MS spectral data and elemental analysis. The detailed synthesis, spectroscopic data, LD50 and pharmacological activities of the synthesized compounds were reported.
机译：通过将2，6-二羟基异烟酰胺酰肼1和2-氯-6-肼基异烟酰胺酰肼11与不同的有机试剂进行初始缩合，合成了一系列新型的噻唑啉衍生物2-15。药理学筛选显示，与作为参考药物的双氯芬酸钾，Voltarene®，Carbamazepine®和Benzotropene®相比，这些化合物中的许多具有良好的抗炎，止痛，抗惊厥和抗帕金森病活性。最初，通过测定化合物的LD 50 来测定其急性毒性。通过IR， 1 H-NMR， 13 C-NMR，MS光谱数据和元素分析确认了新合成的化合物的结构。报道了合成化合物的详细合成，光谱数据，LD 50 和药理活性。

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