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首页> 外文期刊>Archives of Environmental Contamination and Toxicology >Hepatic Enzyme Induction and Acute Endocrine Effects of 2,2′,3,3′,4,6′-Hexachlorobiphenyl and 2,2′,3,4′,5′,6-Hexachlorobiphenyl in Prepubertal Female Rats
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Hepatic Enzyme Induction and Acute Endocrine Effects of 2,2′,3,3′,4,6′-Hexachlorobiphenyl and 2,2′,3,4′,5′,6-Hexachlorobiphenyl in Prepubertal Female Rats

机译：青春期前雌性大鼠2,2'，3,3'，4,6'-六氯联苯和2,2'，3,4'，5'，6-六氯联苯的肝酶诱导和急性内分泌作用

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Polychlorinated biphenyls (PCBs) with the liable 2,3,6-substitution are important components of certain commercial mixtures and frequently detected in biota, but little is known about their enzyme induction abilities and possible endocrine-disrupting effects. CB 132 (2,2′,3,3′,4,6′-hexachlorophenyl) and CB 149 (2,2′3,4′,5′,6-hexachlorophenyl) were investigated in weanling female rats dosed intraperitoneally on days 21 and 22 and killed on day 24 of age. Uterotropic response, serum thyroid hormone, and hepatic enzyme induction were examined in prepubertal female rats treated with these two environmentally relevant 2,3,6-substituted chlorobiphenyl (CB) congeners from 8 mg/kg to 96 mg/kg. The readily metabolized CB 132 did not cause any significant increase in all endpoints measured in the present study. On the other hand, CB 149 was a weak PROD and BROD inducer and a modest depleter of serum thyroxine in prepubertal female rats. The finding of thyroid hormone disruption by CB 149 may lead to biologically significant neurobehavioral and neurochemical changes in developing animals via milk lactation.
机译：具有有效的2,3,6-取代作用的多氯联苯（PCBs）是某些商业混合物的重要成分，并且经常在生物区系中被检测到，但对其酶的诱导能力和可能的内分泌干扰作用知之甚少。在几天的腹膜内给药的断奶雌性大鼠中研究了CB 132（2,2'，3,3'，4,6'-六氯苯基）和CB 149（2,2'3,4'，5'，6-六氯苯基） 21岁和22岁，并在24岁时被杀。在青春期前的雌性大鼠中，用这两种与环境有关的2,3,6-取代的氯代联苯（CB）同系物（剂量范围从8 mg / kg至96 mg / kg）检查了促子宫反应，血清甲状腺激素和肝酶的诱导。易于代谢的CB 132在本研究中测量的所有终点均未引起任何显着增加。另一方面，CB 149是青春期前雌性大鼠中弱的PROD和BROD诱导剂，血清甲状腺素的适度消耗者。 CB 149破坏甲状腺激素的发现可能导致发育中的动物通过乳汁泌乳产生生物学上显着的神经行为和神经化学变化。

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    M.-H. Li; P.-C. Hsu; Y. L. Guo;

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    Department of Geography National Taiwan University 1 Section 4 Roosevelt Road Taipei 106 Taiwan R.O.C.;

    Department of Safety Health and Environmental Engineering National Kaohsiung First University of Science and Technology 1 University Road Yuanchau Kaohsiung Taiwan R.O.C.;

    Department of Environmental and Occupational Health National Cheng Kung University Medical College 61 Shiao Tong Road Tainan 70428 Taiwan R.O.C.;

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