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首页> 外文期刊>Archives of Pathology & Laboratory Medicine >Application of Immunohistochemistry to Thyroid Neoplasms
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Application of Immunohistochemistry to Thyroid Neoplasms

机译：免疫组织化学在甲状腺肿瘤中的应用

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CONTEXT: Thyroid lesions with nodular architecture and follicular pattern of growth often pose difficulties in accurate diagnosis during the assessment of cytologic and histologic specimens. The diagnosis of follicular neoplasm on cytology or of follicular tumor of uncertain malignant potential on histology is likely to cause confusion among clinicians and delay effective management of these lesions. Occasionally, thyroid tumors represent unusual or metastatic lesions and their accurate diagnosis requires immunohistochemical confirmation. OBJECTIVE: To review the literature on the applications of immunohistochemistry in the differential diagnosis of thyroid tumors. DATA SOURCES: Relevant articles indexed in PubMed (National Library of Medicine) between 1976 and 2006. CONCLUSIONS: Our review supports the use of ancillary techniques involving a panel of antibodies suitable for immunohistochemistry and molecular analysis in the assessment of thyroid nodules. These tools can improve diagnostic accuracy when combined with standard morphologic criteria.
机译：背景：甲状腺结节状结构和滤泡性生长的病变在评估细胞学和组织学标本时通常难以准确诊断。在细胞学上诊断为滤泡性肿瘤或在组织学上诊断为恶性潜能不佳的滤泡性肿瘤很可能会引起临床医生的困惑并延误这些病变的有效治疗。甲状腺肿瘤有时代表异常或转移性病变，其准确诊断需要免疫组化确认。目的：探讨免疫组织化学技术在甲状腺肿瘤鉴别诊断中的应用。数据来源：1976年至2006年间在PubMed（国家医学图书馆）收录的相关文章。结论：我们的评论支持辅助技术的应用，该技术涉及一组适用于免疫组化和分子分析的抗体，用于评估甲状腺结节。当与标准形态标准结合使用时，这些工具可以提高诊断准确性。

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    《Archives of Pathology & Laboratory Medicine》 |2008年第3期|p.359-371|共13页
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    Sandra Fischer Sylvia L Asa;

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    Sandra Fischer, MD, Sylvia L. Asa, MD, PhDAccepted for publication February 20, 2007.From the Department of Pathology, University Health Network and Toronto Medical Laboratories and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario.The authors have no relevant financial interest in the products or companies described in this article.Reprints: Sylvia L. Asa, MD, PhD, Department of Pathology, University Health Network and Toronto Medical Laboratories, 200 Elizabeth St, 11th Floor, Toronto, Ontario, Canada M5G 2C4 (e-mail: sylvia.asa@uhn.on.ca).,;

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