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首页> 外文期刊>Archives of Pharmacal Research >Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat
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Rhynchophylline down-regulates NR2B expression in cortex and hippocampal CA1 area of amphetamine-induced conditioned place preference rat

机译：乙酰胆碱可下调苯丙胺诱导的条件性地方偏爱大鼠的皮质和海马CA1区NR2B表达

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N-methyl-D-aspartate receptor 2B subunit (NR2B) has an important role in the development of conditioned place preference (CPP) and psychostimulant abuse. Rhynchophylline is presently used to treat central nervous systems diseases and has a non-competitive antagonistic effect on NMDA receptors. In this study, amphetamine was administered in rats (2 mg/kg, s.c., once each day for 4 consecutive days), during which they were treated with rhynchophylline (60 mg/kg, i.p., once each day for the next 3 days). NR2B mRNA and protein expression were examined by in situ hybridization and immunohistochemistry. CPP was induced by amphetamine (2 mg/kg, s.c.) by 4th day in rats. Rhynchophylline effectively reversed the expression of amphetamine-induced CPP and itself did not produce a CPP. Amphetamine-CPP rats showed a significantly increased NR2B mRNA and protein expression in medial prefrontal cortex and hippocampal CA1 areas as compared to the control group. Rhynchophylline reversed NR2B mRNA and protein levels induced by amphetamine but rhynchophylline by itself had no effect on NR2B expression in control rats. These results indicate that rhynchophylline inhibits the expression of amphetamine-induced rewarding effect, and this action might be related to down-regulation of NR2B expression in medial prefrontal cortex and hippocampal CA1 area.
机译：N-甲基-D-天冬氨酸受体2B亚基（NR2B）在条件性位置偏爱（CPP）和精神刺激剂滥用的发展中具有重要作用。鼻茶碱目前用于治疗中枢神经系统疾病，并且对NMDA受体具有非竞争性拮抗作用。在这项研究中，安非他明在大鼠中给药（2 mg / kg，皮下注射，连续4天每天一次），在此期间，他们用乙酰胆碱（60 mg / kg，腹膜内注射，在接下来的3天中每天一次）治疗。通过原位杂交和免疫组织化学检查NR2B mRNA和蛋白表达。在大鼠的第4天，苯丙胺（2 mg / kg，s.c.）诱导CPP。乙酰胆碱能有效地逆转苯丙胺诱导的CPP的表达，而自身不产生CPP。与对照组相比，苯丙胺-CPP大鼠在内侧前额叶皮层和海马CA1区的NR2B mRNA和蛋白表达显着增加。菱形茶碱逆转了苯丙胺诱导的NR2B mRNA和蛋白水平，但菱形茶碱本身对对照组大鼠的NR2B表达没有影响。这些结果表明，乙酰胆碱能抑制苯丙胺诱导的奖励作用的表达，并且该作用可能与下额内侧皮层和海马CA1区NR2B表达的下调有关。

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