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首页> 外文期刊>Archives of Toxicology >Trichloroacetic acid in urine as biological exposure equivalent for low exposure concentrations of trichloroethene
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Trichloroacetic acid in urine as biological exposure equivalent for low exposure concentrations of trichloroethene

机译：尿液中的三氯乙酸与低三氯乙烯浓度的生物暴露相当

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A urinary trichloroacetic acid (TCA) concentration of 100 mg/l at the end of the last work shift (8 h/day, 5 days/week) of the week has been established in workers as exposure equivalent for the carcinogenic substance trichloroethene (EKA for TRI) at an exposure concentration of 50 ppm TRI. Due to the continuous reduction of atmospheric TRI concentrations during the last years, the quantitative relation given by the EKA for TRI is revised for exposures to low TRI concentrations. A physiological two-compartment model is presented by which the urinary TCA concentrations are calculated that result from inhaled TRI in humans. The model contains one compartment for trichloroethanol (TCE) and one for TCA. Inhaled TRI is metabolized to TCA and to TCE. The latter is in part further oxidized to TCA. Urinary elimination of TCA is modeled to obey first order kinetics. All required model parameters were taken form the literature. In order to evaluate the model performance on the urinary TCA excretion at low exposure concentrations, predicted urinary TCA concentrations were compared with data obtained in two volunteer studies and in one field study. The model was evaluated at exposure concentrations as low as 12.5 ppm TRI. It is demonstrated that the correlation described by the hitherto used EKA for TRI is also valid at low TRI concentrations. For TRI exposure concentrations of 0.6 and 6 ppm, the resulting urinary TCA concentrations at the end of the last work shift of a week are predicted to be 1.2 and 12 mg/l, respectively.
机译：在工人的最后一个工作班次（8小时/天，5天/周）结束时，尿中三氯乙酸（TCA）的浓度已确定为100毫克/升，相当于致癌物质三氯乙烯（EKA）的暴露当量对于TRI），暴露浓度为50 ppm TRI。由于最近几年中大气TRI浓度的持续下降，EKA对TRI的定量关系进行了修订，以适应低TRI浓度的暴露。提出了一种生理两室模型，通过该模型可计算出人体吸入的TRI引起的尿中三氯乙酸浓度。该模型包含一个用于三氯乙醇（TCE）的隔室和一个用于TCA的隔室。吸入的TRI被代谢为TCA和TCE。后者部分被进一步氧化为TCA。尿中三氯乙酸的消除被建模为服从一级动力学。所有必需的模型参数均取自文献。为了评估低暴露浓度下尿中TCA排泄的模型性能，将预测的尿中TCA浓度与两项志愿者研究和一项现场研究中获得的数据进行了比较。在低至12.5 ppm TRI的暴露浓度下评估模型。证明了迄今使用的用于TRI的EKA描述的相关性在低TRI浓度下也是有效的。对于TRI暴露浓度为0.6和6 ppm，在一周的最后一个工作班次结束时，所产生的尿TCA浓度预计分别为1.2和12 mg / l。

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