• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Effects of bisphenol A on breast cancer and its risk factors
【24h】

Effects of bisphenol A on breast cancer and its risk factors

机译：双酚A对乳腺癌的影响及其危险因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The incidence of breast cancer in Korea has been increasing for the last two decades (1983–2005), and now, breast cancer is ranked the leading cause of cancer in Korean women. Along with other endocrine disrupting chemicals (EDCs), bisphenol A (BPA) has been suspected as a potential risk factor for breast cancer. We studied potential associations between BPA exposure and breast cancer risks in Korean women by performing biomonitoring of BPA among breast cancer patients and controls (N = 167). Blood samples were collected between 1994 and 1997 and kept over 10 years in a freezer under well controlled conditions. The blood BPA levels determined by HPLC/FD, ranged between LOD (0.012 µg/L) and 13.87 µg/L (mean ± SD, 1.69 ± 2.57 µg/L; median, 0.043 µg/L). In age-matched subjects (N = 152), there were some associations between BPA levels and risks of breast cancer, such as age at first birth and null parity. However, there were no significant differences in blood BPA levels between the cases and the controls (P = 0.42). Considering interactions between BPA exposure and risks of breast cancer, we suggest further enlarged biomonitoring studies of BPA to provide effective prevention against breast cancer.
机译：在过去的二十年（1983-2005年）中，韩国的乳腺癌发病率一直在增长，现在，乳腺癌已成为韩国女性癌症的主要原因。与其他破坏内分泌的化学物质（EDC）一样，双酚A（BPA）也被怀疑是乳腺癌的潜在危险因素。我们通过对乳腺癌患者和对照中的BPA进行生物监测，研究了韩国女性中BPA暴露与乳腺癌风险之间的潜在关联（N = 167）。在1994年至1997年之间收集了血液样本，并在良好控制的条件下将其保存在冰箱中超过10年。通过HPLC / FD测定的血液BPA水平在LOD（0.012 µg / L）和13.87 µg / L之间（平均值±SD，1.69±2.57 µg / L；中位数，0.043 µg / L）。在年龄匹配的受试者（N = 152）中，BPA水平与乳腺癌风险之间存在一定的关联，例如初生年龄和零胎。但是，病例与对照组之间的血液中BPA水平没有显着差异（P = 0.42）。考虑到BPA暴露与乳腺癌风险之间的相互作用，我们建议进一步扩大BPA的生物监测研究，以有效预防乳腺癌。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号