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首页> 外文期刊>Archives of Toxicology >Histopathologic effects of maternal 4-tert-octylphenol exposure on liver, kidney and spleen of rats at adulthood
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Histopathologic effects of maternal 4-tert-octylphenol exposure on liver, kidney and spleen of rats at adulthood

机译：母体4-叔辛基苯酚暴露对成年大鼠肝脏，肾脏和脾脏的组织病理学影响

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摘要

The present study was performed to investigate the potential toxic effects of prenatal exposure to 4-tert-octylphenol (OP) on liver, kidney, spleen, and hematologic parameters of male and female rats in adult life. The rats were treated with OP subcutaneously in utero at doses of control (vehicle, corn oil), 100 or 250 mg/kg per day. After birth, the rats were allowed to grow until adulthood and then liver, kidney and spleen were investigated histopathologically. Also the blood collected from rats were analyzed for any hematologic changes. The red blood cells of male and female rats were decreased in 250 mg/kg per day OP-treated group compared with the control group. μ-RBC of male rats in high dose treatment groups were increased significantly compared with the controls and 100 mg/kg per day treatment groups. μ-RBC of female rats in treatment groups were increased in a dose-dependent manner compared with the controls. In liver, kidney and spleen of male and female rats treated with OP, degeneration of hepatic parenchyma, tubular degeneration and hemorrhage were observed in histopathologic examination. The hemosiderin deposition in spleen of the high-dose group was increased in both male and female rats. In conclusion, findings of this study demonstrate that maternal administration of high doses of OP causes adverse effects on spleen and liver tissues of male and female offsprings at adulthood. Specifically, OP caused decreases in the number of red blood cells indicated by increased destruction in the spleen.
机译：进行本研究以调查产前暴露于4-叔辛基苯酚（OP）对成年雌雄大鼠的肝脏，肾脏，脾脏和血液学参数的潜在毒性作用。大鼠以子宫内皮下OP给予对照剂量（车辆，玉米油），每日100或250 mg / kg。出生后，使大鼠生长直至成年，然后对肝，肾和脾进行组织病理学检查。还分析了从大鼠收集的血液的任何血液学变化。每天250 mg / kg的OP治疗组与对照组相比，雄性和雌性大鼠的红细胞减少。与对照组和每天100 mg / kg的治疗组相比，高剂量治疗组的雄性大鼠的μ-RBC显着增加。与对照组相比，治疗组雌性大鼠的μ-RBC以剂量依赖性方式增加。组织病理学检查发现，经OP处理的雄性和雌性大鼠的肝，肾和脾脏中，肝实质变性，肾小管变性和出血。高剂量组脾脏中的铁血黄素沉积在雄性和雌性大鼠中均增加。总之，这项研究的结果表明，母亲大剂量服用OP会对成年后的雄性和雌性后代的脾脏和肝脏组织产生不利影响。具体而言，OP引起的脾脏破坏增加表明红细胞数量减少。

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