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首页> 外文期刊>Archives of Toxicology >Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk
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Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk

机译：GSTM3内含子6变异与吸烟，咀嚼烟草和酒精作为前列腺癌风险调节因子的关联

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摘要

Variations in glutathione-S-transferases (GSTs) genes may alter the catalytic efficiency of GST isoenzymes leading to potential increase in susceptibility to carcinogens present in cigarette smoke and tobacco. The present study aimed to explore the association of GSTM3 intron 6 polymorphism with susceptibility to prostate cancer (PCa), and to assess risks associated with cigarette smoking, tobacco chewing and alcohol consumption in PCa patients of North India. The study included 135 PCa patients and 169 controls. All subjects were genotyped for 3-bp deletion in intron 6 of GSTM3. Risk of developing prostate cancer associated with GSTM3 AB + BB was 2.5-fold (OR = 2.51, P = 0.028) as compared to AA genotype. Patients who were either smokers and/or had alcohol habits demonstrated a strong association with GSTM3 (AB + BB) genotype (OR = 4.11, P = 0.046; OR = 4.38, P = 0.027, respectively). Our results suggested GSTM3 (AB + BB) genotype to be significantly associated with PCa risk. The risk was even more apparent in case of cigarette smokers and alcohol consumers.
机译：谷胱甘肽-S-转移酶（GSTs）基因的变异可能会改变GST同工酶的催化效率，从而导致卷烟和烟草中存在的致癌物敏感性增加。本研究旨在探讨GSTM3内含子6多态性与前列腺癌（PCa）易感性的关系，并评估印度北部PCa患者与吸烟，咀嚼和饮酒相关的风险。该研究包括135名PCa患者和169名对照。对所有受试者的GSTM3内含子6中的3-bp缺失进行基因分型。与AA基因型相比，发生与GSTM3 AB + BB相关的前列腺癌的风险是2.5倍（OR = 2.51，P = 0.028）。吸烟者和/或有饮酒习惯的患者表现出与GSTM3（AB + BB）基因型的强烈关联（分别为OR = 4.11，P = 0.046； OR = 4.38，P = 0.027）。我们的结果表明，GSTM3（AB + BB）基因型与PCa风险显着相关。对于吸烟者和饮酒者而言，这种风险更加明显。

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