• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Effect of α-tocopherol on carbon tetrachloride intoxication in the rat liver
【24h】

Effect of α-tocopherol on carbon tetrachloride intoxication in the rat liver

机译：α-生育酚对大鼠肝脏中四氯化碳中毒的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Carbon tetrachloride (1 ml/kg body weight as a 1:1 mixture of CCl4 and mineral oil) was orally administered to rats. After 12 h, the activity of plasma ALT (alanine aminotransferase) was significantly higher than that of the control group, and plasma ALT and AST (aspartate aminotransferase) activities significantly increased 24 h after CCl4 administration. These results indicated that the necrotic process had initiated at about 12 h and developed thereafter. After 6–24 h of CCl4 administration, the hepatic level of vitamin C, the most sensitive indicator of oxidative stress, decreased significantly, indicating that oxidative stress was significantly enhanced 6 h after CCl4 intoxication and thereafter. Oral administration of vitamin E (1 ml/kg body weight as a 1:1 mixture of α-tocopherol and mineral oil) 12 h before CCl4 administration caused a significant elevation of liver vitamin E level and ameliorated liver necrosis 24 h after CCl4 intoxication based on plasma AST and ALT. Vitamin E also significantly restored the hepatic vitamin C concentration 12 and 24 h after CCl4 intoxication, demonstrating that vitamin E functioned as an antioxidant. The liver vitamin E concentration was not changed by vitamin E supplementation to rats that did not receive CCl4. This result indicated that vitamin E accumulated in the damaged liver. The activation of JNK, ERK1/2 and p38 MAPK took place 1.5 h after CCl4 administration. Co-administration of α-tocopherol with CCl4 did not affect these early changes in MAPKs.
机译：对大鼠口服四氯化碳（1 ml / kg体重，CCl 4 和矿物油的1：1混合物）。施用CCl 4 后24h，血浆ALT（丙氨酸转氨酶）活性明显高于对照组，而血浆ALT和AST（天冬氨酸转氨酶）活性明显升高。这些结果表明坏死过程大约在12小时后开始并随后发展。给予CCl 4 6-24小时后，最敏感的氧化应激指标维生素C的肝水平显着下降，表明CCl 4后6 h氧化应激显着增强中毒及其后。 CCl 4 给药前12 h口服维生素E（1 ml / kg体重，α-生育酚与矿物油的1：1混合物）可显着提高肝脏的维生素E水平并改善基于血浆AST和ALT的CCl 4 中毒后24小时肝坏死。维生素E还可以在CCl 4 中毒后12和24 h显着恢复肝中维生素C的浓度，表明维生素E具有抗氧化剂的作用。补充维生素E给未接受CCl 4 的大鼠肝脏维生素E浓度没有改变。该结果表明维生素E积累在受损的肝脏中。 CCl 4 给药后1.5 h，JNK，ERK1 / 2和p38 MAPK激活。 α-生育酚与CCl 4 并用不会影响MAPKs的这些早期变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号