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首页> 外文期刊>Archives of Toxicology >Effect of alpha-tocopherol on carbon tetrachloride intoxication in the rat liver.
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Effect of alpha-tocopherol on carbon tetrachloride intoxication in the rat liver.

机译：α-生育酚对大鼠肝脏中四氯化碳中毒的影响。

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Carbon tetrachloride (1 ml/kg body weight as a 1:1 mixture of CCl(4) and mineral oil) was orally administered to rats. After 12 h, the activity of plasma ALT (alanine aminotransferase) was significantly higher than that of the control group, and plasma ALT and AST (aspartate aminotransferase) activities significantly increased 24 h after CCl(4) administration. These results indicated that the necrotic process had initiated at about 12 h and developed thereafter. After 6-24 h of CCl(4) administration, the hepatic level of vitamin C, the most sensitive indicator of oxidative stress, decreased significantly, indicating that oxidative stress was significantly enhanced 6 h after CCl(4) intoxication and thereafter. Oral administration of vitamin E (1 ml/kg body weight as a 1:1 mixture of alpha-tocopherol and mineral oil) 12 h before CCl(4) administration caused a significant elevation of liver vitamin E level and ameliorated liver necrosis 24 h after CCl(4) intoxication based on plasma AST and ALT. Vitamin E also significantly restored the hepatic vitamin C concentration 12 and 24 h after CCl(4) intoxication, demonstrating that vitamin E functioned as an antioxidant. The liver vitamin E concentration was not changed by vitamin E supplementation to rats that did not receive CCl(4). This result indicated that vitamin E accumulated in the damaged liver. The activation of JNK, ERK1/2 and p38 MAPK took place 1.5 h after CCl(4) administration. Co-administration of alpha-tocopherol with CCl(4) did not affect these early changes in MAPKs.
机译：向大鼠口服四氯化碳（1 ml / kg体重，作为CCl（4）和矿物油的1：1混合物）。 12 h后，CCl（4）给药后24 h，血浆ALT（丙氨酸转氨酶）的活性显着高于对照组，并且血浆ALT和AST（天冬氨酸转氨酶）的活性显着增加。这些结果表明坏死过程大约在12小时后开始并随后发展。给予CCl（4）6-24小时后，肝中维生素C（氧化应激的最敏感指标）的水平显着下降，表明氧化应激在CCl（4）中毒后6小时及之后显着增强。在CCl（4）施用前12小时口服维生素E（1毫升/千克体重，以1-生育酚和矿物油的1：1混合物形式）可导致肝脏维生素E水平显着升高，并在24小时后减轻肝脏坏死CCl（4）中毒基于血浆AST和ALT。维生素E还可以在CCl（4）中毒后12和24 h显着恢复肝中维生素C的浓度，表明维生素E起到抗氧化剂的作用。补充维生素E的未接受CCl（4）的大鼠肝脏的维生素E浓度没有改变。该结果表明维生素E积累在受损的肝脏中。 JCl，ERK1 / 2和p38 MAPK的激活发生在CCl（4）给药后1.5小时。与CCl（4）共同使用α-生育酚不会影响MAPKs的这些早期变化。

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