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首页> 外文期刊>Archives of Toxicology >Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension
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Evidence of early involvement of matrix metalloproteinase-2 in lead-induced hypertension

机译：基质金属蛋白酶2早期参与铅诱发的高血压的证据

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Lead exposure increases blood pressure (BP) by unknown mechanisms. Many recent studies have shown the involvement of matrix metalloproteinases (MMPs) in hypertension, particularly MMP-2. In this work, we have examined whether MMP-2 levels increase with lead-induced increase in BP. We have also investigated whether doxycycline (an MMP inhibitor) affects these alterations. To this end, rats were exposed to lead (90 ppm) and treated with doxycycline or vehicle for 8 weeks. Similar aortic and whole blood lead levels were found in lead-exposed rats treated with either doxycycline or vehicle. Lead-induced increases in BP and aortic MMP-2 levels (activity, protein, and mRNA) were blunted by doxycycline. Doxycycline also prevented lead-induced increases in the MMP-2/TIMP-2 mRNA ratio. No significant changes in vascular reactivity or morphometric parameters were found. In conclusion, lead exposure increases BP and vascular MMP-2, which is blunted by doxycycline. This observation suggests that MMP-2 may play a role in lead-induced increases in BP.
机译：铅暴露通过未知机制增加血压（BP）。最近的许多研究表明，基质金属蛋白酶（MMP）与高血压特别是MMP-2有关。在这项工作中，我们检查了MMP-2水平是否随铅诱导的BP增加而增加。我们还研究了强力霉素（一种MMP抑制剂）是否会影响这些改变。为此，将大鼠暴露于铅（90 ppm）中，并用强力霉素或赋形剂处理8周。在用强力霉素或赋形剂治疗的铅暴露大鼠中，发现了相似的主动脉和全血铅水平。多西环素抑制了铅诱导的BP和主动脉MMP-2水平（活性，蛋白质和mRNA）增加。强力霉素还阻止了铅诱导的MMP-2 / TIMP-2 mRNA比值的增加。没有发现血管反应性或形态学参数的显着变化。总之，铅暴露会增加BP和血管MMP-2，这会被强力霉素削弱。该观察结果表明，MMP-2可能在铅诱导的BP升高中起作用。

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