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首页> 外文期刊>Archives of Toxicology >Transplacental and early life exposure to inorganic arsenic affected development and behavior in offspring rats
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Transplacental and early life exposure to inorganic arsenic affected development and behavior in offspring rats

机译：经胎盘和生命早期暴露于无机砷影响后代大鼠的发育和行为

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摘要

To evaluate the developmental neurotoxicity of arsenic in offspring rats by transplacental and early life exposure to sodium arsenite in drinking water, the pregnant rats or lactating dams, and weaned pups were given free access to drinking water, which contained arsenic at concentrations of 0, 10, 50, 100 mg/L from GD 6 until PND 42. A battery of physical and behavioral tests was applied to evaluate the functional outcome of pups. Pups in arsenic exposed groups weighed less than controls throughout lactation and weaning. Body weight of 10, 50 and 100 mg/L arsenic exposed groups decreased significantly on PND 42, 16 and 12, respectively. Physical development (pinna unfolding, fur appearance, incisor eruption, or eye opening) in pups displayed no significant differences between control and arsenic treated groups. The number of incidences within the 100 mg/L arsenic treated group, in tail hung, auditory startle and visual placing showed significant decrease compared to the control group (p < 0.05). In square water maze test, the trained numbers to finish the trials successfully in 50 and 100 mg/L arsenic exposed groups increased remarkably compared to control group, and there was a dose-related increase (p < 0.01) observed. Taken together, these data show that exposure of inorganic arsenite to pregnant dams and offspring pups at levels up to 100 mg/L in drinking water may affect their learning and memory functions and neuromotor reflex.
机译：为了通过经胎盘和生命早期暴露于饮用水中的亚砷酸钠评估后代大鼠中砷的发育神经毒性，对怀孕的大鼠或哺乳期母鼠和断奶幼仔免费提供饮用水，其中砷的浓度为0、10从GD 6到PND 42分别为50、100 mg / L。应用一系列身体和行为测试来评估幼犬的功能结局。在整个泌乳和断奶期间，砷暴露组的幼仔体重都比对照组小。 PND 42、16和12分别使10、50和100 mg / L砷暴露组的体重显着下降。幼犬的身体发育（耳廓展开，皮毛外观，门牙萌出或睁眼）在对照组和砷治疗组之间没有显示出显着差异。与对照组相比，在100 mg / L砷处理组中，在尾部悬挂，听觉惊吓和视觉放置中的发生次数显着降低（p <0.05）。在方形水迷宫测试中，与对照组相比，暴露于50和100 mg / L砷暴露组中成功完成试验的受训人数明显增加，并且观察到剂量相关的增加（p <0.01）。综上所述，这些数据表明，无机砷暴露于孕妇水坝和后代幼崽的饮用水中浓度高达100 mg / L可能会影响其学习和记忆功能以及神经运动反射。

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