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首页> 外文期刊>Biological trace element research >Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in offspring rats.
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Distribution and speciation of arsenic by transplacental and early life exposure to inorganic arsenic in offspring rats.

机译：经胎盘和生命早期暴露于后代大鼠的无机砷中砷的分布和形态。

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The amount of arsenic compounds was determined in the liver and brain of pups and in breast milk in the pup's stomach in relation to the route of exposure: transplacental, breast milk, or drinking water. Forty-eight pregnant rats were randomly divided into four groups, each group was given free access to drinking water that contained 0, 10, 50, and 100 mg/L NaAsO(2) from gestation day 6 (GD 6) until postnatal day 42 (PND 42). Once pups were weaned, they started to drink the same arsenic-containing water as the dams. Contents of inorganic arsenic (iAs), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and trimethylarsenic acid (TMA) in livers and brains of the pups on PND 0, 15, 28, and 42 and breast milk taken from the pup's stomach on PND 0 and 15 were detected using the hydride generation atomic absorption spectroscopy method. Concentrations of iAs, MMA, and DMA in the breast milk, the brain, and the liver of the pups increased with the concentration of arsenic in drinking water on PND 0, 15, 28, and 42. Compared to the liver or brain, breast milk had the lowest arsenic concentrations. There was a significant decrease in the levels of arsenic species on PND 15 compared to PND 0, 28, or 42. It was confirmed that arsenic species can pass through the placental barrier from dams to offspring and across the blood-brain barrier in the pups, and breast milk from dams exposed to arsenic in drinking water contains less arsenic than the liver and brain of pups.
机译：确定幼犬肝脏和大脑中以及幼犬胃中母乳中砷的含量与接触途径有关：胎盘，母乳或饮用水。从妊娠第6天（GD 6）到出生后第42天，将48只怀孕的大鼠随机分为四组，每组可免费获得含有0、10、50和100 mg / L NaAsO（2）的饮用水。 （PND 42）。幼仔断奶后，他们开始喝与大坝相同的含砷水。在PND 0、15、28和42的幼犬的肝脏和大脑以及取自幼犬的母乳中，肝脏和大脑中无机砷（iAs），一甲基砷酸（MMA），二甲基砷酸（DMA）和三甲基砷酸（TMA）的含量使用氢化物​​发生原子吸收光谱法检测PND 0和15上的胃。幼犬的母乳，大脑和肝脏中iAs，MMA和DMA的浓度随饮用水中PND 0、15、28和42上砷的浓度增加而增加。与肝脏或大脑相比，母乳牛奶中砷的含量最低。与PND 0、28或42相比，PND 15上的砷种类水平显着降低。已证实砷种类可以从大坝到后代穿过胎盘屏障，并穿过幼仔的血脑屏障。 ，而从大坝中暴露于饮用水中砷的母乳中所含的砷含量要比幼犬的肝脏和大脑中的砷含量低。

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