• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Lactational coumestrol exposure increases ovarian apoptosis in adult rats
【24h】

Lactational coumestrol exposure increases ovarian apoptosis in adult rats

机译：乳香香豆酚暴露可增加成年大鼠卵巢凋亡

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, and 10 mg/kg COU during the lactation period and the reproductive effects of female pups were investigated in young adults. Rats were sacrificed at postnatal days (PND) 81–84. Ovarian weights were reduced significantly at 0.1 and 1.0 mg/kg COU. The reduction in the ovarian weight occurred in parallel with an increase in the apoptosis at PND 135–140. A marked dose-dependent increase in the expressions of active caspase-3 and -7 was observed in ovarian granulosa cells. Immunostaining for active caspase-3 and the TUNEL staining of apoptotic cells were also increased in ovaries exposed to COU in a dose-dependent manner. These results suggest new sights into the effect of lactational exposure to COU on the female reproductive health.
机译：这项研究是第一个研究在哺乳期暴露于强效植物雌激素香豆酚（COU）后成年大鼠卵巢细胞凋亡增加的研究。在哺乳期以0.01、0.1、1和10 mg / kg COU的剂量灌胃泌乳大坝，并研究了成年雌性幼崽的生殖作用。在出生后第81-84天处死大鼠。在0.1和1.0 mg / kg COU时，卵巢重量显着降低。卵巢重量减少与PND 135–140处的细胞凋亡增加同时发生。在卵巢颗粒细胞中观察到活性caspase-3和-7的表达具有明显的剂量依赖性。在暴露于COU的卵巢中，活性caspase-3的免疫染色和凋亡细胞的TUNEL染色也以剂量依赖性方式增加。这些结果表明，人们对哺乳期暴露于COU对女性生殖健康的影响有了新的认识。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号