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首页> 外文期刊>Archives of Toxicology >Lactational coumestrol exposure increases ovarian apoptosis in adult rats.
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Lactational coumestrol exposure increases ovarian apoptosis in adult rats.

机译：乳香香豆酚的暴露会增加成年大鼠的卵巢细胞凋亡。

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This study is the first to examine the increased apoptosis in the adult rat ovary after lactational exposure to coumestrol (COU), a potent phytoestrogen. Lactating dams were gavaged at doses of 0.01, 0.1, 1, and 10 mg/kg COU during the lactation period and the reproductive effects of female pups were investigated in young adults. Rats were sacrificed at postnatal days (PND) 81-84. Ovarian weights were reduced significantly at 0.1 and 1.0 mg/kg COU. The reduction in the ovarian weight occurred in parallel with an increase in the apoptosis at PND 135-140. A marked dose-dependent increase in the expressions of active caspase-3 and -7 was observed in ovarian granulosa cells. Immunostaining for active caspase-3 and the TUNEL staining of apoptotic cells were also increased in ovaries exposed to COU in a dose-dependent manner. These results suggest new sights into the effect of lactational exposure to COU on the female reproductive health.
机译：这项研究是第一个研究哺乳期暴露于强效植物雌激素香豆酚（COU）后成年大鼠卵巢细胞凋亡增加的研究。在哺乳期以0.01、0.1、1和10 mg / kg COU的剂量对哺乳期母乳进行灌胃，并研究了成年幼崽对雌性幼崽的生殖作用。在出生后第81-84天处死大鼠。在0.1和1.0 mg / kg COU时，卵巢重量显着降低。卵巢重量减少与PND 135-140处的细胞凋亡增加同时发生。在卵巢颗粒细胞中观察到活性caspase-3和-7的表达具有明显的剂量依赖性。在暴露于COU的卵巢中，活性caspase-3的免疫染色和凋亡细胞的TUNEL染色也以剂量依赖性方式增加。这些结果表明，人们对哺乳期暴露于COU对女性生殖健康的影响有了新的认识。

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