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首页> 外文期刊>Archives of Virology >Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005
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Sequence and phylogenetic analysis of Newcastle disease virus genotypes isolated in Malaysia between 2004 and 2005

机译：2004年至2005年在马来西亚分离的新城疫病毒基因型的序列和系统发育分析

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Sequence analysis of the fusion (F) gene of eight Malaysian NDV isolates showed that all the isolates were categorized as velogenic viruses, with the F cleavage site motif 112R-R-Q-K-R116 or 112R-R-R-K-R116 at the C-terminus of the F2 protein and phenylalanine (F) at residue 117 at the N-terminus of the F1 protein. Phylogenetic analysis revealed that all of the isolates were grouped in two distinct clusters under sub-genotype VIId. The isolates were about 4.8–11.7% genetically distant from sub-genotypes VIIa, VIIb, VIIc and VIIe. When the nucleotide sequences of the eight Malaysian isolates were compared phylogenetically to those of the old published local isolates, it was found that genotype VIII, VII, II and I viruses exist in Malaysia and caused sporadic infections. It is suggested that genotype VII viruses were responsible for most of the outbreaks in recent years.
机译：对八个马来西亚NDV分离株的融合（F）基因进行的序列分析表明，所有分离株均被分类为velogenic病毒，具有F切割位点基序 112 RRQKR 116 或< F 2 蛋白C端的sup> 112 RRRKR 116 ，F 端的117位残基的苯丙氨酸（F） sub> 1 蛋白。系统发育分析表明，所有分离株都归为VIId亚型，分为两个不同的簇。这些分离株与亚基因型VIIa，VIIb，VIIc和VIIe的遗传距离约为4.8-11.7％。当将八个马来西亚分离株的核苷酸序列与已发表的旧本地分离株的系统发育进行比较时，发现马来西亚存在基因型VIII，VII，II和I，并引起了零星的感染。有人认为，基因型VII病毒是近年来大多数爆发的原因。

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