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首页> 外文期刊>Archives of Virology >Variability of the S gene of hepatitis B virus in southeastern China
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Variability of the S gene of hepatitis B virus in southeastern China

机译：中国东南部乙型肝炎病毒S基因的变异性

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In a study of 315 HBV specimens obtained from southern China, 240 (76.9%) were assigned to genotype B, 72 (22.9%) were genotype C, two (0.6%) were genotype A and one (0.3%) was genotype D. Statistical analysis revealed that variables such as age, gender, HBV vaccination rate, hepatitis anamnesis rate, anti-HBs and HBeAg prevalence and virus load were insignificant between genotype B (n = 240) and genotype C cases (n = 72) (P > 0.05). However, the frequency of amino acid (aa) substitutions in the major hydrophilic region (MHR; aa 99–169) and the putative HLA class I-restricted cytotoxic T lymphocyte (CTL) epitope region of the S gene, as well as the overlapping polymerase/RT region (aa 32–212), were significantly higher in genotype C group than genotype B (P < 0.001). These results suggest that the higher variability within genotype C carriers may account for the pathogenic potential.
机译：在一项对来自中国南方的315例HBV标本的研究中，将240个（76.9％）归为基因型B，将72个（​​22.9％）归为基因型C，将两个（0.6％）归为基因型A，将一个（0.3％）归为基因型D.统计分析显示，在基因型B（n = 240）和基因型C（n = 72）病例之间，年龄，性别，HBV疫苗接种率，肝炎复诊率，抗HBs和HBeAg患病率和病毒载量等变量无关紧要（P> 0.05）。但是，主要亲水区域（MHR； aa 99–169）和假定的HLA I类限制的细胞毒性T淋巴细胞（CTL）表位区域的氨基酸（aa）取代频率以及重叠基因型C组的聚合酶/ RT区域（aa 32–212）显着高于基因型B（P <0.001）。这些结果表明，基因型C携带者内部较高的变异性可能是造成致病性的潜在原因。

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