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Molecular Surgery for the Treatment of Malignant Tumors: Bioincompatible Material Apheresis for Cancer Therapy?

机译：分子手术治疗恶性肿瘤：生物不相容性材料在癌症治疗中的应用吗？

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Controlled immunological shock, induced by bioincompatible material apheresis for cancer (BIC MAC) therapy, produces an immunoactive status in experimental subjects. However, in order to provide a safe, painless, effective, and reproducible BIC MAC therapy, it is mandatory to provide general anesthesia with endotracheal intubation not only during apheresis procedures of 1-h duration but also for an additional 5?h. Using this procedure, there was no mortality experienced during animal experiments. Also, there were no procedurally related physical or sensory abnormalities demonstrated. This general anesthesia of 6?h covered not only the initial 30?min of the hypotension and hypoxic stages but also the recovery stages to hemodynamically normalize the experimental animals. After 6?h, the accumulated leukocytes in the lung are released back to the systemic circulation. In general, granulocytes decreased almost 100% while lymphocytes decreased only 40–50%. During these 6?h, increases of cytokines (tumor necrosis factor-, interleukin-6, etc.) sometimes up to 1000 times occurred. After the 6-h procedure, leukocytes returned nearly to preoperative levels but tended to be continuously increased. After the fourth day, leukocyte counts more than doubled. These cellular and humoral activations were normalized after 2 weeks. These studies were conducted on six normal mongrel dogs. Currently, similar studies are planned to be conducted on tumor-bearing experimental animals. This procedurally induced immunoactivation by apheresis may be able to produce effective apoptosis in malignant tumor cells.
机译：由生物不相容性材料血液分离术治疗癌症（BIC MAC）引起的受控免疫休克在实验对象中产生免疫活性状态。但是，为了提供安全，无痛，有效且可重现的BIC MAC治疗，不仅在持续1小时的单采过程中，还要进行5？h的时间，必须在气管内插管下进行全身麻醉。使用该程序，在动物实验期间没有死亡。而且，没有发现与程序相关的身体或感觉异常。全身麻醉时间为6小时，不仅涵盖了最初的30分钟低血压和低氧阶段，还包括了恢复阶段，以使实验动物的血流动力学正常化。 6小时后，肺中积累的白细胞释放回体循环。通常，粒细胞减少了近100％，而淋巴细胞仅减少了40-50％。在这6小时内，有时会发生多达1000次的细胞因子（肿瘤坏死因子，白介素6等）增加。经过6小时的手术后，白细胞几乎恢复到术前水平，但趋于持续增加。第四天后，白细胞计数增加了一倍以上。这些细胞和体液激活在2周后恢复正常。这些研究是对六只正常的杂种狗进行的。目前，计划对荷瘤实验动物进行类似的研究。程序性地通过单采血液分离术诱导的免疫激活可能能够在恶性肿瘤细胞中产生有效的细胞凋亡。

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