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首页> 外文期刊>Asian Journal of Andrology >Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis
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Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis

机译：褪黑素对链脲佐菌素诱导的糖尿病大鼠睾丸脂质过氧化和抗氧化酶的影响

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Aim: To examine the effects of melatonin treatment on lipid peroxidation (LPO) and the activities of antioxidant enzymes in the testicular tissue of streptozotocin (STZ)-induced diabetic rats. Methods: Twenty-six male rats were randomly divided into three groups as follows: group I, control, non-diabetic rats (n = 9); group Ⅱ, STZ-induced, untreated diabetic rats (n - 8); group Ⅲ, STZ-induced, melatonin-treated (dose of 10 mg/kg·day) diabetic rats (n = 9). Following 8-week melatonin treatment, all rats were anaesthetized and then were killed to remove testes from the scrotum. Results: As compared to group Ⅰ, in rat testicular tissues of group Ⅱ, increased levels of malondialdehyde (MDA) (P < 0.01) and superoxide dismutase (SOD) (P < 0.01) as well as decreased levels of catalase (CAT) (P < 0.01) and glutathione peroxidase (GSH-Px) (P > 0.05) were found. In contrast, as compared to group Ⅱ, in rat testicular tissues of group Ⅲ, levels of MDA decreased (but this decrease was not significant, P > 0.05) and SOD (P < 0.01) as well as CAT (P < 0.05) increased. GSH-Px was not influenced by any of the treatment. Melatonin did not significantly affect the elevated glucose concentration of diabetic group. At the end of the study, there was no significant difference between the melatonin-treated group and the untreated group by means of body and testicular weight. Conclusion: Diabetes mellitus increases oxidative stress and melatonin inhibits lipid peroxidation and might regulate the activities of antioxidant enzymes of diabetic rat testes.
机译：目的：探讨褪黑素治疗对链脲佐菌素（STZ）诱导的糖尿病大鼠睾丸组织脂质过氧化（LPO）和抗氧化酶活性的影响。方法：将26只雄性大鼠随机分为三组：第一组，对照组，非糖尿病大鼠（n = 9）；第二组为非糖尿病大鼠。 Ⅱ组，STZ诱导的未治疗的糖尿病大鼠（n-8）； Ⅲ组，STZ诱导的褪黑素治疗（10 mg / kg·天的剂量）糖尿病大鼠（n = 9）。褪黑激素治疗8周后，麻醉所有大鼠，然后将其杀死以从阴囊中除去睾丸。结果：与Ⅰ组相比，Ⅱ组大鼠睾丸组织中丙二醛（MDA）和超氧化物歧化酶（SOD）的含量升高（P <0.01），过氧化氢酶（CAT）的含量降低（P <0.01）。发现P <0.01）和谷胱甘肽过氧化物酶（GSH-Px）（P> 0.05）。相反，与Ⅱ组相比，Ⅲ组大鼠睾丸组织中MDA水平下降（但下降不显着，P> 0.05），SOD（P <0.01）和CAT（P <0.05）上升。 GSH-Px不受任何治疗的影响。褪黑激素并未显着影响糖尿病组血糖升高。在研究结束时，褪黑激素治疗组和未治疗组在体重和睾丸重量方面无显着差异。结论：糖尿病增加了氧化应激，褪黑素抑制了脂质过氧化，可能调节了糖尿病大鼠睾丸的抗氧化酶活性。

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